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      Crosstalk among strenuous exercise, IL-6, and S-Protein Based Vaccines for COVID-19 may explain the rare adverse effects of myocarditis and thrombosis in recently vaccinated young people. A prospective observational study.

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        1 , , 2 , 3 , 4
      ScienceOpen Preprints
      COVID-19, vaccination , myocarditis, thrombosis, IL-6



            Interleukin 6 (IL-6) is a type of interleukin that functions as both a pro-inflammatory and anti-inflammatory cytokine. It is encoded by the IL6 gene in humans. Both COVID-19 infection and S-Protein Based Vaccines for COVID-19 were found to induce the production of pro-inflammatory IL-6, and also, strenuous exercise was found to induce IL-6 secretion by the skeletal muscles via lactate. Exercise causes skeletal muscle cells to release IL-6, and it raises the plasma concentration of IL-6 100 times higher than at rest. Exercise-induced IL-6 release is highly correlated with exercise intensity and duration; thus, IL-6 is regarded as an energy sensor released by contracting muscles. Although, COVID-19 infection and S-Protein Based Vaccines for COVID-19 have similar pathological effects, such as myocardial infarction, thrombotic and coagulation abnormalities (deep thrombosis), but these adverse effects are rarely associated with S-Protein Based Vaccines for COVID-19. Recently, it was shown that most patients who experienced myocarditis after the COVID-19 vaccine were young male youth aged 16 to 29 years had the highest incidence of myocarditis. Interestingly, It was observed that IL-6 was linked to adverse effects such as thrombosis and myocarditis, both of which are similar to that was caused by COVID-19 infection, and that S-Protein based vaccines for COVID-19. Here, we propose a testable hypothesis that strenuous exercise could be a risk and cofactor helping in the existence of these adverse effects in young people such as myocarditis and thrombosis via induction of the secretion of proinflammatory IL-6. In our retrospective and prospective observational study, we will assess the possible correlation among strenuous exercise, IL-6, myocarditis, and thrombosis. The study will be multi-center and will involve a young patient who will be vaccinated with first, second, and third doses of S-Protein Based Vaccines for COVID-19 (Moderna and Pfizer-BioNTech vaccine). Pfizer and BioNTech have successfully developed the BNT162b2 mRNA vaccine, which consists of the full-length S glycoprotein with the K986P and V987P mutation sites. Also, Moderna's mRNA-1273 vaccine contains the coding sequence for an S glycoprotein stabilized by a pair of proline substitutions (K986P/V987P), a transmembrane anchor, and an intact S1-S2 cleavage site



            Author and article information

            ScienceOpen Preprints
            21 December 2021
            [1 ] Department of chemistry and biochemistry, Faculty of Science, Damietta University, Egypt
            [2 ] Department of chemistry, College of Science , University of Tabuk , Saudia Arabia
            [3 ] Director of tuberculosis program Ghubera, public health department ,First health cluster ,Ministry of health , Riyadh, Saudia Arabia
            [4 ] Professor of Sport Nutrition (Sport Nutritionist) Exercise Physiology Department, College of Sports Science and Physical Activity (King Saud University, Riyadh)
            Author notes

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            : 21 December 2021
            no no

            All data generated or analysed during this study are included in this published article (and its supplementary information files).
            Medicine,Life sciences
            vaccination ,thrombosis,myocarditis,IL-6,COVID-19



            Distinguished researchers, writers, commentators, and editors of the scientific community.

            Mahmoud Elkazzaz is an idea and article thief. He is a dishonorable and shameless man. He stole my ideas and articles. Now he is running a slander and smear campaign. This person who violates all ethical rules has no place in the scientific community. This person is extremely dangerous for science and humanity. He is a pharaoh. He is such a dishonorable man that he did not return the money I sent as an article publication fee. And he tries to use it against him in different ways. I share this evidence, receipts, and correspondence images with journal editors.
            Congratulations to the editor of Science open and the editors of Frontiers Neuroendocrine for being fair and retracting articles that were stolen from me.

            He deleted my name from the most recent GPCR in-silicone article and published the article in MDPI Vaccines. He violated all ethical values by making false statements to the editors about conflicts of interest.
            I expect the editors of MDPI Vaccines to act fairly and ethically. Necessary evidence was shared with them.

            My name is deleted by Elkazzaz from the other four articles that I have written and developed for months and sent to peer-reviewed journals. Anticipating this situation, I also wrote about it in this plagiarism article. My name was deleted from the GPCR article and published in the MDPI Vaccines journal. Likewise, my name was deleted from the Isotretinoin article and preprinted in MedRxiv. I leave this situation, which is a serious violation of ethical rules, to the discretion of you, dear readers and editors.
            These articles with my name on the list of authors in preprint versions
            It was previously withdrawn by the neuroendocrine editors of scienceopen and Frontiers due to the same problem. I hope these articles will be retracted by other journal editors along with the evidence I will present.
            During the acceptance of the GPCR article by Frontiers, this thief extorted the 650 dollars I sent to Elkazzaz for the article publication fee.
            All correspondence and evidence regarding this process are presented to the editors by me. The editors are withdrawing the articles considering this evidence. I hope that this fair approach is demonstrated by other journal editors.
            I would like to present to your appreciation the email I wrote to the editor of the relevant journal since my name was removed from the GPCR article and published in the MDPI Vaccines journal.
            Elkazzaz continues to plagiarize my previous articles on retinoid signaling disorder in the pathogenesis of COVID-19. Violating all ethical and moral rules, this man is a complete charlatan. It has the potential to harm people because of its greed and madness. This thief has no place in the scientific community.

            Below are four preprint articles that I rewrote and developed and added my name. Then my name will probably be removed from this articles by Elkazzaz

            1. Regarding the efficacy of LZTRL1 and COVID-19 vaccines

            2. Identification of the STRA6 receptor as the binding receptor of the SARS-CoV-2 spike protein

            by molecular docking

            3. Identification of GPCR receptors as binding receptor of SARS-CoV-2 spike protein by

            molecular docking

            4. Article of the clinical trial study on the determination of the efficacy of 13-Cis retinoic acid

            (isotretinoin) in COVID-19 patients


            Dear. prof. Dr. Ralph A. Tripp, Editor-in-Chief vaccines MD
            Dear Academic Editors: Ger Rijkers and Jean-Luc Murk

            RE: Article of GPCR.

            Elkazzaz M, Ahmed A, Abo-Amer YE-E, Hydara T, Haikal A, Razek DNAE, Eltayb WA, Wang X, Karpiński TM, Hamza D, Jabbar B, Shamkh IM. In Silico Discovery of GPCRs and GnRHRs as Novel Binding Receptors of SARS-CoV-2 Spike Protein Could Explain Neuroendocrine Disorders in COVID-19. vaccines 2022; 10(9):1500. https://doi.org/10.3390/vaccines10091500

            Since the beginning of the COVID-19 pandemic, I have written 8-10 articles published in international peer-reviewed journals on the pathogenesis of COVID-19.
            My team and I conducted the first study in Turkey in which retinol levels were examined in CVD-19 patients. This study was first published in MedRxiv preprint and then in Clinical Nutrition open science.

            Sarohan AR, Akelma H, Araç E, Aslan Ö, Cen O. Retinol Depletion in COVID-19. Clin Nutr Open Sci. 2022 Jun;43:85-94. doi: 10.1016/j.nutos.2022.05.007. Epub 2022 May 28. PMID: 35664529; PMCID: PMC9142171

            The idea of ​​retinol depletion and retinoid signaling disorder in the pathogenetic of COVID-19 belongs to me, and I brought the related molecules, mechanisms, and pathways to the literature. The endogenous retinoic acid theory and retinoic acid depletion syndrome you wrote for this purpose were published in medical hypotheses in 2020.

            Sarohan AR. COVID-19: Endogenous Retinoic Acid Theory and Retinoic Acid Depletion Syndrome. Med Hypotheses. 2020 Nov;144:110250. doi: 10.1016/j.mehy.2020.110250. Epub 2020 Sep 10. PMID: 33254555; PMCID: PMC7481114

            As a continuation of this article, retinol depletion and retinoid signaling disorder in the pathogenesis of COVID-19 was published in the journal cellular signaling.

            Sarohan AR, Kızıl M, Inkaya AC, Mahmud S, Akram M, Cen O. A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder. Cell Signal. 2021 Nov;87:110121. doi: 10.1016/j.cellsig.2021.110121. Epub 2021 Aug 23. PMID: 34438017; PMCID: PMC8380544.

            During this period, I did not meet the Egyptian Mahmoud Elkazzaz. We met this person because he plagiarized my first article in a preprint he wrote and did not refer to my name. By commenting under the published article, I stated that my article was quoted and not properly cited.

            Thereupon, Mahmoud Elkazzaz contacted me on linkedin and offered to cooperate and asked for my phone number. In the next period, our conversations continued over the WhatsApp application. Within the framework of this collaboration, Elkazzaz sent me four articles on whatsapp for me to rewrite and improve. All interviews continued for 5-6 months in the form of correspondence via whatsapp. All correspondence and evidence is in my phone memory.

            Elkazzaz sent me 4 preprinted articles via whatsapp. I have rewritten these articles and improved their content in terms of retinoid signaling and many other aspects. The GPCR article published in your journal is one of these articles. Whatsapp correspondence that the GPCR letter was mostly written by me and sent to Mahmoud Elkazzaz via Whatsapp application is presented in the e-mail attachment.

            In these studies, I added my thoughts, ideas, and findings regarding the relationship of STRA and GPCR receptors with retinoid signaling defects.
            I also wrote a new review and analysis article on the multi-receptor mechanism and retinoid signaling disorder in CVD-19 pathogenesis. Elkazzaz contributed nothing to this article. He didn't even know I was writing this article. When the article was finished, I sent it to him via whatsapp to add his own name and friends as a gesture. This treacherous man deleted my name and preprinted this article I sent on the evening of February 19 in Scienceopen magazine on his behalf. Later, the related documents were shared by the science open editor  I shared it with Dr. Alexandr Grossman. Based on the evidence I have provided, this article has been retracted and published on the same site on my behalf.

            https://www.scienceopen.com/hosted-document?doi=10.14293/S2199-1006.1.SOR-.PPXLYQW.v1 (retracted article)

            In the meantime, I wrote a plagiarism article to share all the unethical practices with the scientific community. The article is accessible as a preprint to osf preprint and science open preprint.


            He was preprinting by adding my name to the articles I wrote in a period of 4-5 months. After all the articles were written by me, he deleted my name and started sending the articles to the journals. He betrayed me after all the work was done. It turns out that this charlatan was malicious from the beginning and used me in a very dirty way. This immoral thief called Mahmut Elkazzaz has no place in the scientific mosque.

            My name was also on the preprint versions of the GPCR article published in your journal. Before you, this article was accepted by the Frontiers Neuroendocrine exchange. However, the article was rejected at the last minute because Mahmoud Elkazzaz removed my name from the list of authors and added Chinese Xiling Wang, who had nothing to do with this work, as co-author in my place. You can find proof of this in the attachment of the e-mail. I even sent Mahmoud Elkazzaza over western Union the $650 that I had for the publication of the magazine. Elkazzaz did not return this money to me either. The relevant receipt is presented in the attached documents.

            Due to my objection and the evidence I presented, Frontiers magazine stopped publishing the article at the last minute. I present all the evidence to your attention as an attachment to this e-mail.
            In the GPCR article, I wrote the content of the relationship of GPCR receptors with retinoid signaling, the abstract, introduction, discussion part and all other sub-titles of the article. The sentence structures, emphases, and writing order in the article belong to me. If you review the articles I have written before, you will see that many of the sentences are the same as the sentences in my previous articles (systemic organ involvement in CVD-19 and retinoid signaling disorder article and others).

            Sarohan, A. R. "Systemic organ involvement and retinoid signaling disorder in COVID-19." Immunogenetics: Open Access 6.3 (2021): 1-6.
            Note that my name is among the authors in the GPCR article accepted by Frontiers. Below. Related email messages are attached.
            Ahmed, A., Haydara, T., Abo-Amer, Y. E. E., & Sarohan, A. R. Identification of GPCRs as a binding receptor of novel SARS-CoV-2 spike protein, in-silico discovery: scientific breakthrough to explain neuroendocrine disorders in COVID -19. Frontiers in Endocrinology, 1606.

            In conclusion, I am the co-author and co-author of this article published in your journal on September 8, 2022. Publishing this article anonymously is a serious ethical violation. I want this article removed as soon as possible. As MDPI journal group editors, I know you care about ethical values. It is my natural right to demand something that I have worked hard for. I hope you will act fairly in this regard. It would not be nice if the name of the MDPI Vaccines journal is contaminated by such an unethical publication. I applied to court because of this victimization. I would like you to remove this article from access immediately so that your journal is not harmed by this ongoing judicial process.

            Kind regards.
            Dr. Aziz Rodan Sarohan
            Science open preprints editor on the subject, Dr. Alexander Grossman, and Chief Editor of Frontiers Neuroendocrine Science,  the e-mails I sent to Dr. Olfa Masmoudi-Kouki are attached.


            2022-10-03 12:46 UTC

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