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      COVID-19 And SARS-COV-2 Infection And Virulence: Hypothesis I

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      COVID-19, SARS-COV-2, Infectivity, Virulence, DP10000 Number

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          Abstract

          SARS-COV-2 is the etiologic agent of COVID-19. There is currently no effective means of preventing infections by SARS-COV-2, except through restriction of population movement and contact. An understanding of the origin, evolution and biochemistry (molecular biology) of SARS-COV-2 is a prerequite to its control. There is no definitive answer as to the origin of SARS-COV-2. The evolution of SARS-COV-2 can be gleaned from a comparative study of its infectivity and virulence in different populations and environments. From an analysis of the infectivity and virulence of SARS-COV-2 in different parts of the world, it is submitted that there is no correlation between infectivity and virulence of SARS-COV-2. It is therefore hypothesized that SARS-COV-2 may be a rapidly mutating virus and identification of SARS-COV-2 strain(s) that has/have increased virulence is essential in the formulation of any effective vaccine or prophylactic that targets SARS-COV-2.

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          Author and article information

          Journal
          ScienceOpen Preprints
          ScienceOpen
          10 April 2020
          Affiliations
          [1 ] Nachbraht Biomedical Research Institute
          Article
          10.14293/S2199-1006.1.SOR-.PPXVKPX.v1

          This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

          The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

          Biochemistry, Molecular medicine, Molecular biology, Microbiology & Virology

          DP10000 Number, COVID-19, SARS-COV-2, Infectivity, Virulence

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