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      Norovirus: Vaccine Challenges and Development

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            Abstract

            Noroviruses are a group of single-stranded RNA pathogens that cause acute gastroenteritis worldwide. Due to the high rates of mutation and evolution in the viruses, creating an effective vaccine to treat norovirus has been difficult. Factors such as the type of vaccine – live attenuated, subunit, or virus like particles – and target age group have limited progress in development. To better understand the best vaccine types and target groups for norovirus vaccine development, continuous research on the subjects will be encouraged. It will be shown that use of virus-like particles (VLPs) and a pediatric target group are the most effective options due to the versatility of VLPs and higher projected norovirus prevention rates for pediatric vaccination. The result of research will be useful to scientists creating norovirus vaccines and will help provide new perspectives for future research.

            Content

            Author and article information

            Journal
            ScienceOpen Preprints
            ScienceOpen
            18 November 2021
            Affiliations
            [1 ] Department of Biology, North Carolina A & T State University, 1601 E Market Street, Greensboro NC USA
            [2 ] Department of Biological Science, Winston-Salem State University, 601 S Martin Luther King Jr Dr, Winston Salem NC USA
            Author notes
            Article
            10.14293/S2199-1006.1.SOR-.PPYGOKU.v1
            6a79329e-8c51-46d9-94e0-56b808c64cef

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .


            All data generated or analysed during this study are included in this published article (and its supplementary information files).
            Microbiology & Virology,Life sciences
            norovirus,vaccine,challenges,development

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            Comments

            This article is in great condiction. There were a few paragraph that were not indented, that can be fixed. - C. McClendon

            2022-06-20 17:43 UTC
            +1

            This article is in great condition. There were a few paragraph that were not indented, that can be fixed. - C. McClendon

            2022-06-20 17:42 UTC
            +1

            This article is in great condition. There were a few paragraph that were not indented, that can be fixed. - C. McClendon

            2022-06-20 17:42 UTC
            +1

            This article is in great condition. There were a few paragraphs that were not indented, that can be fixed. - C. McClendon

            2022-06-20 17:41 UTC
            +1

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