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      Why acute inflammatory response can happen after Adenoviral Vector Vaccines; Is the interleukin 6 the secret and how circumvent that, Is by adding polyethylene glycol (PEG)?

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            Summary

            Adenoviral vector vaccines induce an acute immunogenic response that varies according to the 
            immune status of the individuals injected. The excipient used in the vaccine injection can either 
            increase or decrease the severity of this acute immune response. For example, polyethylene 
            glycol can decrease IL-6 while polysorbate 80 or EDTA can increase severity. In comparison 
            to Americans or Asians, Africans have neutralizing antibodies against the chimpanzee
            adenoviral vector, which can result in a less acute immunogenic response (less adverse effects). 
            Thus, it is necessary to administer ChAdox1 nCov2 to African populations in order to avoid 
            the vaccine's acute immunogenic impact in neutralizing antibodies existence (vaccine less 
            effective). The question after discussing the acute immune response from adenovirus vectors 
            (IL-6 is has a role) and Is adding polyethylene glycol to adenoviral vector vaccine lessen the 
            vaccine adverse effects.

            Abstract

            After one year of pandemic SARS COV2, which started in December 2019, it is still considered a health disaster in all nations. Despite vaccination efforts, the number of infected people increased, also the number of SARS COV2 variants increased. Certain vaccinations are approved under Emergency Use Authorization, including those dependent on mRNA technology, like those developed by Pfizer-BioNTech and Moderna (FDA Emergency Use Authorization EUA), as well as those dependent on Adenovirus vectors, like those developed by AstraZeneca (covishield, AZD1222 vaccine. (ChAdOx1) (WHO permission) and Johnson and Johnson, (FDA suspended 13/4/2021 use FDA and CDC suggested the stop use of COVID-19 (Janssen & Janssen) vaccination when reviewing details of six U.S. case-rare and serious blood clot cases identified in vaccine-receiving individuals). The optimal vaccine will have a low sero prevalence of neutralizing antibodies against the viral vector and a low incidence of adverse events. The protection of non-human adenovirus vectors used in humans is a primary concern. Global efforts against covid-19 continue, and vaccine production has intensified. Adenoviral vector vaccines induce an acute immunogenic response that varies according to the immune status of the individuals injected. The excipient used in the vaccine injection can either increase or decrease the severity of this acute immune response. For example, polyethylene glycol can decrease IL-6 while polysorbate 80 or EDTA can increase severity. In comparison to Americans or Asians, Africans have neutralizing antibodies against the chimpanzee adenoviral vector, which can result in a less acute immunogenic response (less adverse effects). Thus, it is necessary to administer ChAdox1 nCov2 to African populations in order to avoid the vaccine's acute immunogenic impact in neutralizing antibodies existence (vaccine less effective). The question after discussing the acute immune response from adenovirus vectors (IL-6 is has a role) and Is adding polyethylene glycol to adenoviral vector vaccine lessen the vaccine adverse effects.

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            Author and article information

            Journal
            ScienceOpen Preprints
            ScienceOpen
            7 May 2021
            Affiliations
            [1 ] Department of public Health, Tuberculosis program, Ministry of Health,Saudia Arabia
            [2 ] 2Department of Biochemistry, Port-Said University, Egypt.
            [3 ] 3Faculty of Dentistry, the British University in Egypt, Cairo, Egypt.
            [4 ] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, the British University in Egypt, Cairo, Egypt.
            Article
            10.14293/S2199-1006.1.SOR-.PPYJ404.v1
            cdc9f449-1664-497c-a3bd-6513bf996f0d

            This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

            Funding
            none none

            The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
            Pharmaceutical chemistry
            Covid-19 vaccine,Zinc,African people,Polysorbate 80,Polyethylene glycol (PEG),IL-6,inflammatory response,mRNA vaccine,Adenoviral vector vaccine,EDTA

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