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      Organocatalysts for enantioselective synthesis of fine chemicals: definitions, trends and developments

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          Abstract

          Organocatalysis, that is the use of small organic molecules to catalyze organic transformations, has been included among the most successful concepts in asymmetric catalysis, and it has been used for the enantioselective construction of C–C, C–N, C–O, C–S, C–P and C–halide bonds. Since the seminal works in early 2000, the scientific community has been paying an ever-growing attention to the use of organocatalysts for the synthesis, with high yields and remarkable stereoselectivities, of optically active fine chemicals of interest for the pharmaceutical industry. A brief overview is here presented about the two main classes of substrate activation by the catalyst: covalent organocatalysis and non-covalent organocatalysis, with a more stringent focus on some recent outcomes in the field of the latter and of hydrogen bond-based catalysis. Finally, some successful examples of heterogenization of organocatalysts are also discussed, in the view of a potential industrial exploitation.

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          Most cited references 73

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          Green chemistry: principles and practice.

          Green Chemistry is a relatively new emerging field that strives to work at the molecular level to achieve sustainability. The field has received widespread interest in the past decade due to its ability to harness chemical innovation to meet environmental and economic goals simultaneously. Green Chemistry has a framework of a cohesive set of Twelve Principles, which have been systematically surveyed in this critical review. This article covers the concepts of design and the scientific philosophy of Green Chemistry with a set of illustrative examples. Future trends in Green Chemistry are discussed with the challenge of using the Principles as a cohesive design system (93 references).
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            Catalytic Asymmetric Dihydroxylation

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              Asymmetric Catalysis: Science and Opportunities (Nobel Lecture) Copyright© The Nobel Foundation 2002. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.

               Ryoji Noyori (2002)
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                Author and article information

                Contributors
                (View ORCID Profile)
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                Journal
                SOR-CHEM
                ScienceOpen Research
                ScienceOpen
                2199-1006
                03 March 2015
                : 0 (ID: 8e6b1b2d-670e-45ff-a11f-b7bbc31f38e5 )
                : 0
                : 1-14
                Affiliations
                CNR-Institute of Molecular Sciences and Technologies, Via C. Golgi 19, Milan, Italy
                Author notes
                [* ]Corresponding author's e-mail address: chiara.palumbo@ 123456istm.cnr.it
                Article
                2627:XE
                10.14293/S2199-1006.1.SOR-CHEM.AGZIIB.v2
                © 2015 C. Palumbo and M. Guidotti.

                This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

                Page count
                Figures: 19, Tables: 0, References: 107, Pages: 14
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