Blog
About
Search
Advanced search

238
views
87
references
 Top references
0
cited by
 Most cited
    
1 reviews
 Review
0
comments
 Comment
2
recommends
+1 Recommend
1 collections
    10
    shares
    16,206
    similar
     All similar
    • Record: found
    • Abstract: found
    • Article: found
    Is Open Access

    Lipids contribute to epigenetic control via chromatin structure and functions

    This is not the latest version for this article. If you want to read the latest version, click here.

    Read this article at

    ScienceOpen
    Bookmark
        There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

        Abstract

        Isolated cases of experimental evidence over the last few decades have shown that, where specifically tested, both prokaryotes and eukaryotes have specific lipid molecules bound to nucleoproteins of the genome. In vitro, some of these lipids exhibit stoichiometric association with DNA polynucleotides with differential affinities toward certain secondary and tertiary structures. Hydrophobic interactions with inner nuclear membrane could provide attractive anchor points for lipid-modified nucleoproteins in organizing the dynamic genome and accordingly there are precedents for covalent bonds between lipids and core histones and, under certain conditions, even DNA. Advances in biophysics, functional genomics, and proteomics in recent years brought about the first sparks of light that promises to uncover some coherent new level of the epigenetic code governed by certain types of lipid–lipid, DNA–lipid, and protein–lipid interactions among other biochemical lipid transactions in the nucleus. Here, we review some of the older and more recent findings and speculate on how critical nuclear lipid transactions are for individual cells, tissues, and organisms.

        Related collections

        Most cited references 87

        • Record: found
        • Abstract: found
        • Article: not found

        Global quantification of mammalian gene expression control.

         Dorothea Busse,  Gunnar Dittmar,  Wei-Chen Shieh … (2011)
        Gene expression is a multistep process that involves the transcription, translation and turnover of messenger RNAs and proteins. Although it is one of the most fundamental processes of life, the entire cascade has never been quantified on a genome-wide scale. Here we simultaneously measured absolute mRNA and protein abundance and turnover by parallel metabolic pulse labelling for more than 5,000 genes in mammalian cells. Whereas mRNA and protein levels correlated better than previously thought, corresponding half-lives showed no correlation. Using a quantitative model we have obtained the first genome-scale prediction of synthesis rates of mRNAs and proteins. We find that the cellular abundance of proteins is predominantly controlled at the level of translation. Genes with similar combinations of mRNA and protein stability shared functional properties, indicating that half-lives evolved under energetic and dynamic constraints. Quantitative information about all stages of gene expression provides a rich resource and helps to provide a greater understanding of the underlying design principles.
        Article 0 comments Cited 1056 times – based on 0 reviews     Review now
          Bookmark
          • Record: found
          • Abstract: found
          • Article: not found

          The language of covalent histone modifications.

           Brian Strahl,  C. David Allis (2000)
          Histone proteins and the nucleosomes they form with DNA are the fundamental building blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often occur on tail domains of these proteins has been well documented. Although the function of these highly conserved modifications has remained elusive, converging biochemical and genetic evidence suggests functions in several chromatin-based processes. We propose that distinct histone modifications, on one or more tails, act sequentially or in combination to form a 'histone code' that is, read by other proteins to bring about distinct downstream events.
          Article 0 comments Cited 863 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Membrane lipids: where they are and how they behave.

             Gerald Feigenson,  Gerrit van der Wal,  Dennis Voelker (2008)
            Throughout the biological world, a 30 A hydrophobic film typically delimits the environments that serve as the margin between life and death for individual cells. Biochemical and biophysical findings have provided a detailed model of the composition and structure of membranes, which includes levels of dynamic organization both across the lipid bilayer (lipid asymmetry) and in the lateral dimension (lipid domains) of membranes. How do cells apply anabolic and catabolic enzymes, translocases and transporters, plus the intrinsic physical phase behaviour of lipids and their interactions with membrane proteins, to create the unique compositions and multiple functionalities of their individual membranes?
            Article 0 comments Cited 598 times – based on 0 reviews     Review now
              Bookmark
              All references

              Author and article information

              Affiliations
              [1 ]Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008 and Russian Institute for Advanced Study at Moscow Pedagogical State University, Moscow 119571 Russian Federation
              [2 ]Wellcome Trust Centre for Cell Biology, University of Edinburgh, Kings Buildings, Michael Swann Bldg., Max Born Crescent, Edinburgh EH9 3BF, UK
              [3 ]MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
              [4 ]Department of Biosciences, P.O. Box 65 (Viikinkaari 1), 00014, University of Helsinki, Helsinki, Finland
              Author notes
              [* ]Corresponding author's e-mail address: kagasha@ 123456yahoo.com
              Contributors
              Renad Zhdanov: (View ORCID Profile)
              Eric C. Schirmer: (View ORCID Profile)
              Anuroop V. Venkatasubramani: (View ORCID Profile)
              Alastair R. W. Kerr: (View ORCID Profile)
              Elena Mandrou: (View ORCID Profile)
              Giovanny Rodriguez-Blanco: (View ORCID Profile)
              Alexander Kagansky: (View ORCID Profile)
              Journal
              Journal ID (publisher-id): SOR-LIFE
              Title: ScienceOpen Research
              Publisher: ScienceOpen
              ISSN (Electronic): 2199-1006
              Publication date 06 October 2015
              Volume: 0 (ID: 8feb0edb-4724-4f85-9bd4-fd3b0eee2868 )
              Issue: 0
              Pages: 1-11
              Publisher ID: 3127:XE
              DOI: 10.14293/S2199-1006.1.SOR-LIFE.AUXYTR.v1
              Copyright statement: © 2015 Zhdanov et al.

              License:

              This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

              Counts
              Figures: 2, Tables: 2, References: 81, Pages: 11
              Product
              Categories
              Subject: Original article

              Comments

              Comment on this article