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      We are delighted to announce that CVIA has received its first Journal Impact Factor (0.5) in the 2023 Journal Citation Reports Release.

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      In-Hospital Cardiac Arrest after Emotional Stress in a Patient Hospitalized with Gastrointestinal Symptoms and Chronic Anxiety Disorder



            Background: We report an acute emotional stress–induced in-hospital cardiac arrest in a patient admitted with gastrointestinal symptoms after experiencing chronic anxiety disorder.

            Case Presentation: The patient was admitted to the Second Xiangya Hospital, Central South University, with gastrointestinal symptoms and chronic anxiety disorder, and experienced cardiac arrest during hospitalization after acute emotional stress. Malignant ventricular tachycardia and cardiogenic shock were evidenced in this patient after the acute emotional stress. Severe and extensive coronary spasm was confirmed by emergency coronary angiography, and coronary spasm was relieved by intracoronary injection of nitroglycerin. The patient recovered from myocardial infarction with nonobstructive coronary arteries. However, the patient developed acute kidney dysfunction and severe pulmonary infection and eventually died of respiratory circulatory failure on the ninth day after the successful rescue.

            Conclusions: Acute emotional stress on top of chronic anxiety disorder in patients hospitalized for noncardiovascular reasons might lead to the development of life-threatening cardiovascular diseases, including coronary artery spasm and myocardial infarction with nonobstructive coronary arteries. Psychological management is of importance to improve the outcome of these patients.

            Main article text


            Emotional stress can enhance sympathetic activity, leading to endothelial dysfunction and vascular smooth muscle hyperreactivity, and can sometimes even induce acute coronary artery spasm (CAS) [1]. CAS may be the underlying mechanism in up to 10% of cases of sudden cardiac death in patients with acute coronary syndrome (ACS) [2]. Psycho-emotional disorders and CAS are the common pathological causes of myocardial infarction with nonobstructive coronary arteries (MINOCA) [3]. Intervention for psycho-emotional disorders was shown to be the medical target for both prevention and recovery in some patients with MINOCA [4].

            Gastrointestinal dysfunction is a common concomitant symptom in patients with chronic emotional disorders [5]. However, the cardiovascular risk is often overlooked in these hospitalized patients because of gastrointestinal symptoms, accompanied by psychological problems. Herein, we report a relevant case of a middle-aged patient with chronic anxiety disorder hospitalized with gastrointestinal symptoms who experienced cardiac arrest during hospitalization after acute emotional stress.

            Case Presentation

            A 53-year-old man was admitted to the Department of Gastroenterology of our hospital with a 6-month history of intermittent black stool and fatigue, aggravated for 3 days. He had also experienced generalized anxiety disorder, hypertension, and intermittent chest pain for 7 months before admission. He had a suspected diagnosis of coronary heart disease and had been treated with rosuvastatin and trimetazidine for 7 mouths. He had no history of diabetes, hyperlipemia, or any other cardiovascular risk factor. He was a long-term smoker (around 30 years) and had quit smoking 7 months before hospitalization. He had no cocaine consumption history and no family history of sudden cardiac death. The patient had received no antianxiety drugs for personal reasons.

            On admission, his blood pressure was 116/72 mmHg and his heart rate was 72 beats per minute. His heart, lung, and abdomen physical examination results were normal. His liver function test results, renal function test results, electrolyte levels (serum potassium 4.55 mmol/L, serum magnesium 0.93mmol/L, serum sodium 137.6 mmol/L, and serum calcium 2.11 mmol/L), myocardial enzyme level, and troponin T level at admission were normal. His hemoglobin level was reduced (87 g/L), and an occult blood test was positive. Standard 12-lead electrocardiogram (ECG) demonstrated borderline T wave changes in lateral leads (V5, V6, I, aVL), with no features of ST-segment elevation myocardial infarction (Figure 1A).

            Figure 1

            Electrocardiogram (ECG).

            (A) Admission 12-lead ECG showing borderline T wave changes in lateral leads. (B) The ECG showed ST-segment elevations in inferior leads (II, III, aVF), depression in anterior leads (V2–V5), and an abnormal Q wave in inferior leads (II, III, aVF). (C) Sustained ventricular tachycardia occurred after the abnormal changes on the ECG. (D) The ECG after resuscitation.

            He was treated initially with pantoprazole, sucralfate, and nifedipine. Continuous bleeding of the digestive tract was controlled on the next morning after admission. After breakfast, he suddenly experienced very strong emotional stress owing to some trivial family matters. He asked the physician in charge of his medication to “attenuate” his discomfort, including severe chest pain and shortness of breath. Emergency management was immediately initiated, and the ECG showed ST elevations in inferior leads (II, III, aVF), depression in anterior leads (V2–V5), and an abnormal Q wave in inferior leads (II, III, aVF); see Figure 1B. His symptoms could not be relieved by oxygen therapy and nitroglycerin. A few minutes later, the patient became unconsciousness, his blood pressure dropped to shock status, and ECG monitoring evidenced ventricular fibrillation following transient ventricular tachycardia (Figure 1C). During the 90-minute cardiopulmonary resuscitation period, the patient received unsynchronized cardioversion five times, mechanical ventilation, large doses of vasoactive agents, and continuous intravenous norepinephrine infusion (0.5 μg/kg·min). The patient’s vital signs were finally restored, and his blood pressure and heart rate recovered to 101/70 mmHg and 97 beats per minute, respectively. The high-sensitivity troponin T value was 2,518 pg/mL (0.01–14.00 pg/mL is the normal reference range for troponin instrument detection) immediately after recovery. Coronary angiography was performed immediately after resuscitation and evidenced diffuse arterial narrowing in three coronary arteries: the left anterior descending coronary artery (95% stenosis, TIMI grade 1), the left circumflex artery (95% stenosis, TIMI grade 2), and the right coronary artery (95% stenosis, TIMI grade 1); see Figure 2. Ventriculography showed global left ventricular hypokinesia, and wall motion abnormality was more significant in the mid wall (Figure 3A; left ventricular ejection fraction [LVEF] 33%). After intracoronary injection of nitroglycerin, spasm of all the coronary arteries was resolved completely with TIMI grade 2–3 (Figure 2). Bedside transthoracic echocardiography revealed severe reduced left ventricular function (LVEF 33.4%; Figure 3B). After the successful rescue, symptomatic and supportive treatment was continued. Norepinephrine was used to stabilize blood pressure, nitroglycerin to reduce vasospasm, metoprolol and amiodarone to control ventricular arrhythmia, piperacillin/tazobactam and meropenem to prevent infection, esomeprazole to inhibit gastric acid, and hemodialysis for acute kidney failure. Despite use of a series of treatment methods and the left ventricular motion being slightly improved 7 days later (LVEF 39.7%; Figure 3B), the patient failed to regain consciousness. Ultimately, the patient died of respiratory circulatory failure 9 days later due to cardiac arrest caused by acute kidney failure and severe pulmonary infection.

            Figure 2

            Coronary Angiography.

            Total and subtotal spasm were observed in the whole left anterior descending artery (LAD), the distal portion of the left circumflex artery (LCX), and the whole right coronary artery (RCA). Severe coronary artery spasm was relieved after intracoronary injection of nitroglycerin.

            Figure 3

            Ventriculography and Bedside Transthoracic Echocardiography.

            (A) Focal segment motion abnormality of the mid wall of the left ventricle (black arrow). (B) The left ventricle showed diffuse left ventricular dyskinesia on the first day after cardiac arrest; 7 days later, the left ventricular motion was slightly improved.


            The present case highlights the important clinical impact on cardiovascular outcome of psychological stress in a hospitalized patient with noncardiovascular symptoms.

            Coronary angiography after resuscitation in this patient revealed typical signs of MINOCA, characterized by CAS [6, 7]. In line with a literature report, the underlying reason for CAS was the sudden emotional stress, and CAS could be relieved by intracoronary injection of nitroglycerin [8]. However, the acute emotional stress in our patient occurred on top of chronic psychological disorder. The joint effects of chronic and acute emotional stress might be the potential mechanism for the disease progress and poor outcome (malignant ventricular tachycardia and extensive and reversible CAS, followed by death due to respiratory circulatory failure 9 days after successful resuscitation). The mechanism by which emotional problems lead to cardiac events is possibly related to burst release of stress hormones, including catecholamine.

            Although the LVEF increased slightly from 33.4% to 39.7% after resuscitation after reversible CAS, the patient died of respiratory circulatory failure 9 days later in the presence of new-onset acute kidney failure and severe pulmonary infection. The present patient was admitted to the Department of Gastroenterology because of digestive symptoms. By reviewing the case afterwards, we found that the psychological problems and the potential risk of cardiovascular burden were not given enough attention by the managing medical professionals, despite the existing cardiovascular risk factors, including the long-term smoking history of the patient.

            Psycho-emotional disorders are closely related to the risk of CAS and MINOCA [8]. The mechanism by which CAS develops in patients with a history of anxiety or depression seems multifactorial. Endothelial dysfunction and elevated levels of proinflammatory cytokines have been suggested in patients with psychological problems and patients with CAS [8]. Autonomic dysfunction with disruption of the neuroendocrine axis and inflammation/oxidative stress may jointly lead to a state of altered smooth muscle reactivity that predisposes to CAS [8]. Meanwhile, another study indicated that the presence of psychiatric illnesses was higher in patients with MINOCA than in patients with myocardial infarction with obstructive coronary arteries. Such a relationship remained after the exclusion of takotsubo cardiomyopathy [3]. These findings can be explained by the effects of emotions on adrenergic regulation and its relationship with endothelium function [9]. For our patient, 7 months of anxiety formed the basis of CAS, and the acute emotional stress became the last straw to break the camel’s back.


            In conclusion, this case report highlights the importance of managing chronic and acute anxiety disorders in a patient hospitalized for noncardiovascular reasons, especially for patients with potential cardiovascular risks, to prevent the development of CAS and MINOCA.



            Conflicts of Interest

            The authors declare that they have no conflicts of interest.

            Financial Support

            None to declare.


            1. , , , , , , et al. International expert consensus document on takotsubo syndrome (part I): clinical characteristics, diagnostic criteria, and pathophysiology. Eur Heart J 2018;39:2032–46.

            2. , , , , , . Coronary artery spasm as a frequent cause of acute coronary syndrome: the CASPAR (Coronary Artery Spasm in Patients With Acute Coronary Syndrome) study. J Am Coll Cardiol 2008;52:523–7.

            3. , , , , , , et al. Psycho-emotional disorders as incoming risk factors for myocardial infarction with non-obstructive coronary arteries. Cardiol J 2018;25:24–31.

            4. , , , , , , et al. Incidence, clinical profile and prognosis of patients with myocardial infarction with non-obstructive coronary arteries in the real world. J Am Coll Cardio 2017;69(11 Suppl):142.

            5. , , , . The gut-brain axis in health neuroscience: implications for functional gastrointestinal disorders and appetite regulation. Ann N Y Acad Sci 2018;1428(1)129–50.

            6. , , . Myocardial infarction with nonobstructive coronary arteries (MINOCA): the past, present, and future management. Circulation 2017;135:1490–3.

            7. , , , , , . Myocardial Infarction with no obstructive coronary artery disease: angiographic and clinical insights in patients with premature presentation. Can J Cardiol 2018;34:468–76.

            8. , , . Coronary artery spasm, coronary reactivity, and their psychological context. Psychosom Med 2019;81:233–6.

            9. , , , , , , et al. Mental stress induces transient endothelial dysfunction in humans. Circulation 2000;102:2473–8.

            Author and article information

            Cardiovascular Innovations and Applications
            Compuscript (Ireland )
            September 2021
            September 2021
            : 6
            : 1
            : 57-61
            [1] 1Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha City, 410011 Hunan, China
            Author notes
            Correspondence: Shenghua Zhou, Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha City, 410011 Hunan, China, E-mail: zhoushenghua@ 123456csu.edu.cn

            aContributed equally to this paper.

            Copyright © 2021 Cardiovascular Innovations and Applications

            This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

            : 11 April 2021
            : 17 June 2021
            : 1 July 2021
            Case Reports

            General medicine,Medicine,Geriatric medicine,Transplantation,Cardiovascular Medicine,Anesthesiology & Pain management
            coronary artery spasm,psycho-emotional disorders,cardiac arrest,Myocardial infarction with nonobstructive coronary arteries


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