<b>Three dimensional spheroids mimic the tumor microenvironment</b> :   <b>Three dimensional spheroids mimic the tumor microenvironment</b>

Tumors are enclosed by extracellular matrix (ECM) and stromal elements; cellular and acellular components form the tumor microenvironment (TME) (Nyberg, 2008; Wang et al., 2017). The human TME consists of a heterogeneous population of cancer cells including cancer stem cells (CSCs), as well as host stromal cells including cancer-associated fibroblasts (CAFs), mesenchymal stem cells, immune and inflammatory cells, and vascular endothelial cells. Tumor progression and maintenance of the TME is reduced by communication between cells of the TME through adhesive cell surface molecules, secreted soluble factors, and extracellular vesicles (EVs

Content

Author and article information

Journal

Title: AHRO Review of Dentistry

Publisher: AHRO Scientific Publishing

Publication date (Electronic): 13 June 2022

Volume: 1

Issue: 1

Affiliations

[1 ] Department of Epidemiology & Biostatistics, College of Human Medicine, Michigan State University, USA

[2 ] Institute of Quantitative Health Science (IQ), Dept of Biomedical Engineering, Michigan State University, USA

Author notes

[* ]Email: siddikan234@ 123456gmail.com .

Author information

Nazeeba Siddika https://orcid.org/0000-0002-5400-1784

Article

DOI: 10.36295/ARD/2022/02

SO-VID: fb573d4d-2857-462f-92c7-1fba5a25c3cf

License:

This work has been published open access under Creative Commons Attribution License CC BY 4.0 , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com .

History

Date received : 7 June 2022

Date accepted : 11 June 2022

Funding

Nil Nil

Data availability: All data generated or analysed during this study are included in this published article (and its supplementary information files).

ScienceOpen disciplines: Dentistry

Keywords: Tumours,Extracellular Matrix,TME,Cancer-associated fibroblasts,cancer stem cells

References

Wang Maonan, Zhao Jingzhou, Zhang Lishen, Wei Fang, Lian Yu, Wu Yingfeng, Gong Zhaojian, Zhang Shanshan, Zhou Jianda, Cao Ke, Li Xiayu, Xiong Wei, Li Guiyuan, Zeng Zhaoyang, Guo Can. Role of tumor microenvironment in tumorigenesis. Journal of Cancer. Vol. 8(5):761–773. 2017. Ivyspring International Publisher. [Cross Ref]
Salo Tuula, Sutinen Meeri, Hoque Apu Ehsanul, Sundquist Elias, Cervigne Nilva K., de Oliveira Carine Ervolino, Akram Saad Ullah, Ohlmeier Steffen, Suomi Fumi, Eklund Lauri, Juusela Pirjo, Åström Pirjo, Bitu Carolina Cavalcante, Santala Markku, Savolainen Kalle, Korvala Johanna, Paes Leme Adriana Franco, Coletta Ricardo D.. A novel human leiomyoma tissue derived matrix for cell culture studies. BMC Cancer. Vol. 15(1)2015. Springer Science and Business Media LLC. [Cross Ref]
Nyberg Pia. Tumor microenvironment and angiogenesis. Frontiers in Bioscience. Vol. Volume(13)2008. IMR Press. [Cross Ref]
Mehta Geeta, Hsiao Amy Y., Ingram Marylou, Luker Gary D., Takayama Shuichi. Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy. Journal of Controlled Release. Vol. 164(2):192–204. 2012. Elsevier BV. [Cross Ref]
Hoque Apu Ehsanul, Akram Saad Ullah, Rissanen Jouni, Wan Hong, Salo Tuula. Desmoglein 3 – Influence on oral carcinoma cell migration and invasion. Experimental Cell Research. Vol. 370(2):353–364. 2018. Elsevier BV. [Cross Ref]
Hanahan Douglas, Weinberg Robert A.. Hallmarks of Cancer: The Next Generation. Cell. Vol. 144(5):646–674. 2011. Elsevier BV. [Cross Ref]

Comments

Comment on this article

[1] Wang Maonan, Zhao Jingzhou, Zhang Lishen, Wei Fang, Lian Yu, Wu Yingfeng, Gong Zhaojian, Zhang Shanshan, Zhou Jianda, Cao Ke, Li Xiayu, Xiong Wei, Li Guiyuan, Zeng Zhaoyang, Guo Can. Role of tumor microenvironment in tumorigenesis. Journal of Cancer. Vol. 8(5):761–773. 2017. Ivyspring International Publisher. [Cross Ref]

[2] Salo Tuula, Sutinen Meeri, Hoque Apu Ehsanul, Sundquist Elias, Cervigne Nilva K., de Oliveira Carine Ervolino, Akram Saad Ullah, Ohlmeier Steffen, Suomi Fumi, Eklund Lauri, Juusela Pirjo, Åström Pirjo, Bitu Carolina Cavalcante, Santala Markku, Savolainen Kalle, Korvala Johanna, Paes Leme Adriana Franco, Coletta Ricardo D.. A novel human leiomyoma tissue derived matrix for cell culture studies. BMC Cancer. Vol. 15(1)2015. Springer Science and Business Media LLC. [Cross Ref]

[3] Nyberg Pia. Tumor microenvironment and angiogenesis. Frontiers in Bioscience. Vol. Volume(13)2008. IMR Press. [Cross Ref]

[4] Mehta Geeta, Hsiao Amy Y., Ingram Marylou, Luker Gary D., Takayama Shuichi. Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy. Journal of Controlled Release. Vol. 164(2):192–204. 2012. Elsevier BV. [Cross Ref]

[5] Hoque Apu Ehsanul, Akram Saad Ullah, Rissanen Jouni, Wan Hong, Salo Tuula. Desmoglein 3 – Influence on oral carcinoma cell migration and invasion. Experimental Cell Research. Vol. 370(2):353–364. 2018. Elsevier BV. [Cross Ref]

[6] Hanahan Douglas, Weinberg Robert A.. Hallmarks of Cancer: The Next Generation. Cell. Vol. 144(5):646–674. 2011. Elsevier BV. [Cross Ref]