Ultimately, healthcare innovation leads to improved clinical care, with new technology improving healthcare efficiency, effectiveness, quality, and affordability. With ever-increasing demand on health systems worldwide, the ultimate goal of healthcare innovation is to improve the ability to meet public and personal healthcare needs through the optimization of health systems' performance. In this article, we will discuss hospital-based innovation within the next decade that yields scalable solutions within the fields of preventative, treatment, and infection control healthcare innovation.   Governments face tough choices since medical innovations hold promises and perils. These innovations occur across multiple dimensions, including core sciences, drug development, care delivery, and organizational and business models. In particular, medical technology-related innovations are blossoming, with medical technology patents more numerous and growing faster than pharmaceutical patents over the last decade. Despite this enormous investment in innovation and the magnitude of the opportunity for innovators to both do good and do well, all too many efforts fail, losing billions of investor resources along the way. [1] Barriers to disruptive innovation are often the public themselves acting through fear, enacting stringent regulation, supported by established professionals afraid to lose income and hospitals their investment in expensive systems. [2]