Journal Issue Page – ScienceOpen

Volume 4, Issue 1

Issue date: 07 January 2025

Application of a macrocyclization strategy in kinase inhibitor development Kun Xing, Shujun Li, Jinghuan Li …	1
Patient-derived induced pluripotent stem cell organoids for amyotrophic lateral sclerosis drug discovery Wenyan Li, Jingqi Liu, Wenting Li …	36
Comparative drug-drug interactions of berberine and astragaloside IV in normal and type 2 diabetes mellitus rats based on UPLC-QqQ-MS/MS Yan Lei, Jiaqi Xie, Zhongshui Xie …	51
Targeted nanozyme-enabled treatment of cardiovascular diseases Lin Liu, Jie Lv, Xiuxiu Wang …	70
Arenobufagin suppresses the progression of early-stage hepatocellular carcinoma by inhibiting EpCAM-mediated tumor stemness Lijuan Deng, Lifang Zou, Chunhong Zhou …	82
PROTAC technology for prostate cancer treatment Zhen Wang, Dingpeng Zhang, Hiroyuki Inuzuka …	99
Machine learning-powered, high-affinity modification strategies for aptamers Gubu Amu, Xin Yang, Hang Luo …	122
Deciphering the regulatory programs of RNA binding proteins in rheumatoid arthritis through single-cell transcriptome analysis Hongbin Luo, Qunya Zheng, Youzheng Zhou …	137
MiR-128-3p mediates MRP2 internalization in estrogen-induced cholestasis through targeting PDZK1 Yue Zu, Qianyan Gao, Yisheng He …	157
Progress in the structural modification and pharmacological activity of isosteviol Tao Wang, Bowen Pan, Lijuan Liu …	174