Hugo ten Cate, MD PhD

(9-3-1958) POSITION TITLE

Professor of Clinical Thrombosis and Haemostasis and PI, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center

EDUCATION/TRAINING

University of Amsterdam, 1987, Medicine.

University of Amsterdam, 1987, PhD medicine

Division of Hematology-Oncology, Beth Israel Hospital, Harvard Medical School, Boston, USA, postdoctoral fellow

Slotervaarthospital and Academic Medical Center (AMC), Amsterdam, 1996. Training in Internal medicine, board certified internist in vascular medicine

Laboratory for Experimental Internal Medicine, AMC, 1996-2002.

Laboratory Clinical Thrombosis and Hemostasis, Maastricht University Medical center and Cardiovascular Research Institute Maastricht, 2002-

Center for Clinical Thrombosis and Haemostasis, Gutenberg University Medical Center, Mainz; 2012-

BIG nr: 99020447901

CGP: qualified, officially per April 2014.

MD, PhD

Specialist Internal medicine

Full Professor

Clinical thrombosis and hemostasis

A. Positions and Honors (chronological order)

Positions: Internist-vascular medicine and Professor in Internal medicine, Clinical Thrombosis and Hemostasis,Maastricht University Medical Center; head: Maastricht Anticoagulation Clinic.

Chairman of the board, Dutch Federation of Anticoagulation clinics (FNT; 2011-), Member-elect, Council on Thrombosis of the International Society for Thrombosis and Haemostasis (ISTH) (2009-2014), Chairman of the PR & Communications committee of the ISTH (2010-2014). Co-chairman of the Animal Models committee of the ISTH- Scientific SubCommittee. Fellow American Heart Foundation, Member American Society of Hematology. Editorial board: Journal of Thrombosis and Haemostasis, Dataset Papers in Medicine, World Science Journal. Academic Editor, PlosOne. Section editor Thrombosis and Haemostasis; Editor-in-chief (jointly with dr. Yukio Ozaki) Thrombosis Journal.

Honors: Clinical Established Investigatorship, Netherlands Heart Foundation (1996-2002); Gutenberg Research Fellow, Johannes Gutenberg University Mainz, Germany, 2012.

B. Most important recent publications

1: Borissoff J, Spronk HMH, ten Cate H. The hemostatic system as a modulator of atherosclerosis. N Engl J Med. 2011; May 5;364(18):1746-60.

2: Borissoff JI, Heeneman S, Kilinç E, Kassák P, Van Oerle R, Winckers K, Govers-Riemslag JW, Hamulyák K, Hackeng TM, Daemen MJ, ten Cate H, Spronk HM. Early atherosclerosis exhibits an enhanced procoagulant state. Circulation. 2010; 122(8):821-30.

3. Konings J, Govers-Riemslag J, Philippou H, Mutch N, Borissoff J, Allen P, Sumitra, Tans G, ten Cate H, Ariens RA. Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin. Blood 2011;118(14):3942-51. Epub 2011 Aug 9.

4: Siegerink B, Govers-Riemslag JW, Rosendaal FR, Ten Cate H, Algra A. Intrinsic coagulation activation and the risk of arterial thrombosis in young women:results from the Risk of Arterial Thrombosis in relation to Oral contraceptives (RATIO) case-control study. Circulation. 2010;122(18):1854-61.

5: Loubele ST, Spek CA, Leenders P, van Oerle R, Aberson HL, Hamulyák K, Ferrell G, Esmon CT, Spronk HM, ten Cate H. Activated protein C protects against myocardial ischemia/ reperfusion injury via inhibition of apoptosis and inflammation. Arterioscler Thromb Vasc Biol. 2009;29(7):1087-92.