The chapter first looks at the antioxidant properties of flavonoids and their role in preventing auto-immune diseases. It then looks at the anti-microbial, anti-fungal and anti-viral activity of flavonoids and their role in treatment of diabetes. The chapter goes on to discuss the anti-cancer properties of flavonoids and their anti-neoplastic activity in tumour suppression. It also reviews their role in preventing cardiovascular disease and anti-thrombogenic activity of flavonoids, as well as their meuro-protective, anti-ulcerogenic, anti-inflammatory and hepato-protective activity. Finally, the chapter discusses biotechnological approaches for enhanced production of nutraceuticals in fruits and vegetables.