Milestones in the discovery and clinical translation of regulatory T cells (Tregs), a subset of suppressive T lymphocytes that hold the potential to treat autoimmune disorders and organ transplant rejection.
References include seminal studies on murine Tregs, human Tregs, and redirecting T cell specificity via genetic modification, including engineered T cell receptor (TCR) and chimeric antigen receptor (CAR) based approaches.
Main image credit: | https://www.nature.com/articles/s41573-019-0041-4 |
Background image credit: | https://www.nature.com/articles/s41573-019-0041-4 |
ScienceOpen disciplines: | Medicine, Transplantation, Immunology |
Keywords: | Regulatory T cell, Treg, Cell therapy, Autoimmunity, Transplant |
DOI: | 10.14293/S2199-1006.1.SOR-MED.CL3SRKU.v1 |