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    Review of 'Acute and postacute sequelae associated with SARS-CoV-2 reinfection'

    Acute and postacute sequelae associated with SARS-CoV-2 reinfectionCrossref
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        Rated 5 of 5.
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        Rated 5 of 5.
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        Rated 5 of 5.
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        Rated 5 of 5.
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        Rated 5 of 5.
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    Acute and postacute sequelae associated with SARS-CoV-2 reinfection

    First infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risk of acute and postacute death and sequelae in various organ systems. Whether reinfection adds to risks incurred after first infection is unclear. Here we used the US Department of Veterans Affairs’ national healthcare database to build a cohort of individuals with one SARS-CoV-2 infection ( n  = 443,588), reinfection (two or more infections, n  = 40,947) and a noninfected control ( n  = 5,334,729). We used inverse probability-weighted survival models to estimate risks and 6-month burdens of death, hospitalization and incident sequelae. Compared to no reinfection, reinfection contributed additional risks of death (hazard ratio (HR) = 2.17, 95% confidence intervals (CI) 1.93–2.45), hospitalization (HR = 3.32, 95% CI 3.13–3.51) and sequelae including pulmonary, cardiovascular, hematological, diabetes, gastrointestinal, kidney, mental health, musculoskeletal and neurological disorders. The risks were evident regardless of vaccination status. The risks were most pronounced in the acute phase but persisted in the postacute phase at 6 months. Compared to noninfected controls, cumulative risks and burdens of repeat infection increased according to the number of infections. Limitations included a cohort of mostly white males. The evidence shows that reinfection further increases risks of death, hospitalization and sequelae in multiple organ systems in the acute and postacute phase. Reducing overall burden of death and disease due to SARS-CoV-2 will require strategies for reinfection prevention. A new analysis using US Department of Veterans Affairs databases showed that reinfection is associated with increased risk of all-cause mortality, hospitalization and a wide range of long COVID complications in individuals who have had SARS-CoV-2 compared to those with no reinfection.

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      This work has been published open access under Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Conditions, terms of use and publishing policy can be found at www.scienceopen.com.

      viral infection,sars-cov-2
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      Review text

      This statistical study summarized the death, hospitalization and multiple organs-involved sequelae in the cases of reinfection of SARS-CoV-2. Increased risks were observed in terms of death, hospitalization and sequelae upon repeated infections. This is an important study necessary to spread to public, in order to expand our knowledge in SARS-CoV-2 reinfection and advocate effecient prevention methods besides vaccination.


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