In the present study the author summarizes the findings concerning ApoC-III in metabolic imbalance and cardiovascular diseases. This paper focus on mutations present in a minority of individuals and suggests that ApoC-III should be considered as a possible target for pharmacological intervention.
1- The abstract does not address the importance of apolipoprotein C in cardiovascular and metabolic disease. I suggest that the abstract be improved and/or complement the abstract with the previously stated information.
2- In the introduction, the sentence “The overall effects of apoC-III modulation in mice models are supported by genetic association studies in various human populations ”. Please add more than one reference to justify the use of the pluralized version of the noun, “study”. Alternatively, if it has only one citation, please adjust the plural to the singular.
3- The introduction does not have a clear objective. Please include the main goal(s) of the study to better guide the reader.
4- The author discusses the relationships among the genetic factors related to ApoC diseases and concludes that there ought to be a specific potential therapeutic target, and suggests this target. However, there is no strong argumentation that leads to this conclusion in the text. I believe that would be important to describe at least one potential target and add a figure summarizing this pathway.
In the first paragraph of the topic “function”, the author indicates the concentration of ApoC in human body; however, I suggest that the author checks this value in more current studies.
I suggest an overall English review of the manuscript. There are many sentence are difficult to understand.