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Abstract
ACTH (1-24) induces cell shape changes in the immunocytes of the bivalve mollusc,
Mytilus galloprovincialis. Using computer-assisted microscopic image analysis, we
have found that the G protein antagonist suramin sodium, the adenylate cyclase inhibitor
2',5'-dideoxyadenosine, and the protein kinase inhibitor staurosporine inhibit this
effect. The highly specific inhibitors H-89 (for protein kinase A) and calphostin
C (for protein kinase C) only inhibited partially the morphological alterations. In
contrast, the simultaneous action of H-89 and calphostin C completely blocked these
changes. The above findings indicate that ACTH (1-24) induces cell shape changes in
molluscan immunocytes via adenylate cyclase/cAMP/protein kinase A pathway, as well
as the activation of protein kinase C.