A single-atom Fe–N <sub>4</sub> catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

Author(s): Wenjie Ma ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Junjie Mao ⁶ ^, ⁷ ^, ⁸ ^, ⁹ , Xiaoti Yang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Cong Pan ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Wenxing Chen ¹⁰ ^, ¹¹ ^, ¹² ^, ¹³ ^, ⁹ , Ming Wang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Ping Yu ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Lanqun Mao ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Yadong Li ¹⁴ ^, ¹⁵ ^, ¹⁶ ^, ⁹

Publication date (Electronic): 2019

Journal: Chemical Communications

Publisher: Royal Society of Chemistry (RSC)

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Abstract

Single-atom catalysts can serve as single-atom-based enzymes (SAzymes) with multi-antioxidative activities for reactive oxygen species scavenging.

Abstract

Atomically dispersed Fe–N ₄ sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.

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Single-atom catalysis of CO oxidation using Pt1/FeOx.

Botao Qiao, Aiqin Wang, Xiaofeng Yang … (2011)

Platinum-based heterogeneous catalysts are critical to many important commercial chemical processes, but their efficiency is extremely low on a per metal atom basis, because only the surface active-site atoms are used. Catalysts with single-atom dispersions are thus highly desirable to maximize atom efficiency, but making them is challenging. Here we report the synthesis of a single-atom catalyst that consists of only isolated single Pt atoms anchored to the surfaces of iron oxide nanocrystallites. This single-atom catalyst has extremely high atom efficiency and shows excellent stability and high activity for both CO oxidation and preferential oxidation of CO in H2. Density functional theory calculations show that the high catalytic activity correlates with the partially vacant 5d orbitals of the positively charged, high-valent Pt atoms, which help to reduce both the CO adsorption energy and the activation barriers for CO oxidation.