17
views
0
recommends
+1 Recommend
2 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Prevalence and Clinical Presentation of Health Care Workers With Symptoms of Coronavirus Disease 2019 in 2 Dutch Hospitals During an Early Phase of the Pandemic

      Read this article at

      ScienceOpenPublisher
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Key Points Question What was the prevalence and clinical presentation of coronavirus disease 2019 among health care workers with self-reported fever or respiratory symptoms in 2 Dutch hospitals within 2 weeks after the first patient with coronavirus disease 2019 was detected in the Netherlands? Findings In this cross-sectional study that included 1353 health care workers with self-reported fever or respiratory symptoms, 6% were infected with severe acute respiratory syndrome coronavirus 2. Most health care workers with coronavirus disease 2019 experienced mild disease, and only 53% reported fever. Meaning The high prevalence of mild clinical presentations, frequently not including fever, suggests that the currently recommended case definition for suspected coronavirus disease 2019 should be used less stringently.

          Related collections

          Most cited references6

          • Record: found
          • Abstract: found
          • Article: found

          Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

            Background The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that the outbreak is more widespread than initially thought, and international spread through travellers does already occur. Aim We aimed to develop and deploy robust diagnostic methodology for use in public health laboratory settings without having virus material available. Methods Here we present a validated diagnostic workflow for 2019-nCoV, its design relying on close genetic relatedness of 2019-nCoV with SARS coronavirus, making use of synthetic nucleic acid technology. Results The workflow reliably detects 2019-nCoV, and further discriminates 2019-nCoV from SARS-CoV. Through coordination between academic and public laboratories, we confirmed assay exclusivity based on 297 original clinical specimens containing a full spectrum of human respiratory viruses. Control material is made available through European Virus Archive – Global (EVAg), a European Union infrastructure project. Conclusion The present study demonstrates the enormous response capacity achieved through coordination of academic and public laboratories in national and European research networks.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found

              Detection of SARS-CoV-2 in Different Types of Clinical Specimens

              This study describes results of PCR and viral RNA testing for SARS-CoV-2 in bronchoalveolar fluid, sputum, feces, blood, and urine specimens from patients with COVID-19 infection in China to identify possible means of non-respiratory transmission.
                Bookmark

                Author and article information

                Journal
                JAMA Network Open
                JAMA Netw Open
                American Medical Association (AMA)
                2574-3805
                May 01 2020
                May 21 2020
                : 3
                : 5
                : e209673
                Affiliations
                [1 ]Department of Infection Control, Amphia Hospital, Breda, the Netherlands
                [2 ]Amphia Academy Infectious Disease Foundation, Amphia Hospital, Breda, the Netherlands
                [3 ]Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
                [4 ]Laboratory for Medical Microbiology and Immunology, Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands
                [5 ]Department of Infection Control, Elisabeth-TweeSteden Hospital, Tilburg, the Netherlands
                [6 ]Microvida Laboratory for Medical Microbiology, Bravis Hospital, Roosendaal, the Netherlands
                [7 ]Microvida Laboratory for Medical Microbiology, Amphia Hospital, Breda, the Netherlands
                [8 ]Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands
                [9 ]Department of Virology, Erasmus Medical Center, Rotterdam, the Netherlands
                Article
                10.1001/jamanetworkopen.2020.9673
                3fb6b7da-96dc-4902-b467-f0c124f7c315
                © 2020
                History

                Comments

                Comment on this article

                scite_

                Similar content647

                Cited by141

                Most referenced authors681