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      Hallazgos clínicos, bioquímicos y morfológicos en 103 pacientes con anticuerpos contra el virus de la hepatitis C

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          Abstract

          Se estudiaron 103 pacientes portadores de anticuerpos contra el virus de la hepatitis C detectado mediante el empleo del sistema diagnóstico cubano (Anti VHC, CIGB, La Habana). La lesión histológica predominante fue la hepatitis crónica activa (23,2 %), aunque se presentaron 2 casos con hepatitis aguda grave por infección combinada con los virus A y B. En muchos de los enfermos la afección cursó con escasos síntomas. La mayoría de los pacientes eran donantes de sangre y receptores de transfusiones (44,5 %). Estos últimos se relacionaron con las lesiones hepáticas más severas. Se señaló la presencia de portadores sanos del virus.

          Translated abstract

          103 patients carriers of hepatitis C virus antibodies detected by the Cuban diagnostic system (Anti HCV, CIGB, Havana) were studied. Active chronic hepatitis (23.2 %) was the predominant histological lesion, although there were 2 cases with acute severe hepatitis due to a combined infection with A and B viruses. A few symptoms were observed in most of the patients, who were blood donors and blood transfusion receptors (44.5 %). The latter were associated with the most severe hapatic lesions. It is stressed the presence of heal thy carriers of the virus.

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          Most cited references17

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          Classification of chronic hepatitis: Diagnosis, grading and staging

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            A CLASSIFICATION OF CHRONIC HEPATITIS

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              Clinical, biochemical and histological features in 102 patients with chronic hepatitis C virus infection.

              The clinical, biochemical and histological features of 102 consecutively referred patients with chronic hepatitis C virus infection were analysed. Demographic, epidemiological, biochemical, haematological and histological details were catalogued for each patient. The mean follow-up was 49 +/- 6 months. Liver biopsies were obtained from 92 patients; a second biopsy was obtained from 35 patients. The average known duration of infection was 8.6 +/- 0.7 years. The most common risk factors that could be identified were past blood transfusion, surgery or intravenous drug abuse. Twenty-four of the 27 patients (85%) with past blood transfusion had received blood in countries outside of northern Europe. In contrast, 12 of the 16 former drug users were northern European. Patients were frequently diagnosed incidentally; one-quarter had no symptoms of liver disease and were generally asymptomatic or had presented with non-specific complaints and were found to have abnormal serum aminotransferase levels after routine screening. The mean serum aminotransferase levels were not significantly different in those presenting with fatigue compared to those diagnosed incidentally. The most common physical sign in these patients was a palpable liver, which was present in 52%. The mean serum albumin concentration in patients older than 40 years was significantly lower than that in younger patients. Splenomegaly and endoscopic evidence of varices was also more common in older patients. Cirrhosis was present in 37% of patients at presentation: 20% showed progression on rebiopsy, and 5% developed cirrhosis within 4 years of initial presentation. Of those treated, 27% showed histological improvement. Histological severity did not correlate with duration of disease, but did correlate with age.(ABSTRACT TRUNCATED AT 250 WORDS)
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                med
                Revista Cubana de Medicina
                Rev cubana med
                ECIMED (Ciudad de la Habana )
                1561-302X
                June 1998
                : 37
                : 2
                : 66-71
                Affiliations
                [1 ] Instituto Superior de Medicina Militar Dr. Luis Soto Díaz Cuba
                Article
                S0034-75231998000200002
                371f7f02-5df3-4b51-af14-bd78efb35024

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Cuba

                Self URI (journal page): http://scielo.sld.cu/scielo.php?script=sci_serial&pid=0034-7523&lng=en
                Categories
                MEDICINE, GENERAL & INTERNAL
                MEDICINE, LEGAL
                MEDICINE, RESEARCH & EXPERIMENTAL

                Social law,Medicine,Internal medicine
                BLOOD DONORS,VIRUS DE LA HEPATITIS SIMILAR A C,HEPATITIS C-LIKE VIRUSES,HEPATITIS C-LIKE,CARRIER STATE,PORTADOR,DONADORES DE SANGRE,TRANSFUSION SANGUINEA,BLOOD TRANSFUSION

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