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Abstract
Calcinosis cutis (CC) is defined as the deposition of calcium salts in the skin. The
condition is divided into 5 types: calciphylaxis and dystrophic, metastatic, idiopathic,
and iatrogenic CC. Dystrophic CC is the most common form and usually occurs in association
with autoimmune diseases. CC can be treated surgically or with the use of drugs such
as diltiazem, bisphosphonates, warfarin, ceftriaxone, probenecid, minocycline, or
aluminum hydroxide. Calciphylaxis is defined as calcification of the media of small-
and medium-sized blood vessels in the dermis and subcutaneous tissue. Clinically,
calciphylaxis causes livedo racemosa, which progresses to retiform purpura and skin
necrosis. First-line treatment is with sodium thiosulfate. We present a review of
the calcifying disorders of the skin, focusing on their diagnosis and treatment.