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      Photoinduced acute exanthematous pustulosis caused by dicloxacillin and exposure to sunlight

      case-report

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          Abstract

          Photoinduced acute exanthematous pustulosis is a rare condition; only few cases of photo‐AEP have been described previously with drugs such as norfloxacin, ciprofloxacin, and enoxacin. In this case, the reaction is seen after intake of dicloxacillin.

          Abstract

          Photoinduced acute exanthematous pustulosis is a rare condition; only few cases of photo‐AEP have been described previously with drugs such as norfloxacin, ciprofloxacin, and enoxacin. In this case, the reaction is seen after intake of dicloxacillin.

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          [Acute generalized exanthematic pustuloses (four cases) (author's transl)].

          C Beylot, P Bioulac, M S Doutre (2015)
          Acute generalized exanthematic pustuloses supervening without a genetic psoriatic predisposition are not exceptional if the literature over the last few years is taken into account. Such observations are published under a wide range of names. Beside exanthematic pustular psoriasis as defined by Baker and Ryan, there exists in fact a whole scale of amicrobial pustulosis: acute generalized pustular bacterid; acute generalized pustulosis manifestation of leukocytoclastic vasculitis; pustular necroziting angeitis; pustular eruption with eosinophilic abscesses; generalized pustular drug rash; subcorneal pustules in erythema multiforme and in Sweet's syndrome. Thus, it appears that pustuloses exist in many forms, although they have certain common points that justify a synthetic perspective:--their occurrence, after a bout of infection and/or after taking drugs in subjects with no previous known psoriasis;--a single outbreak occurring spontaneously or with corticoid therapy and which heals by itself;--the existence of a marked vasculitis which occurs before the epidermal pustules. Sometimes this takes the form of a leucocytoclastic vasculitis or a polymorphic infiltrate which is rich in intact eosinophils. Direct immunofluorescence shows deposits of C3 and occasionally IgM at the vascular wall. The circulating antibody-antigen complex produced by an infection and/or by a drug may be responsible of the pustulosis by a hypersensibility mechanism (type Arthus phenomen). From the existing literature and the personal observations of four cases, the authors have made a general review of these pustuloses. They believe that in the majority of cases, pustulosis should not be considered as being psoriatic. However, the authors discuss the rare but possible occurrence of such a pustulosis in patients with a genetic psoriatic predisposition. They feel it would be preferable to avoid the publication of observations under a too wide a range of names, and propose the common heading of "acute generalized exanthematic pustulosis".
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            The spectrum of histopathological features in acute generalized exanthematous pustulosis: a study of 102 cases.

            S Halevy, S Kardaun, Batya B Davidovici … (2010)
            Acute generalized exanthematous pustulosis (AGEP) is a rare severe pustular reaction pattern with a typical clinical picture.
            Article 0 comments Cited 17 times – based on 0 reviews     Review now
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              Acute generalized exanthematous pustulosis: report of 12 cases and literature review.

              Elizabeth Guevara-Gutiérrez, E Uribe, Alberto Tlacuilo-Parra … (2009)
              Acute generalized exanthematous pustulosis is an acute pustular eruption occurring after infection and/or drug ingestion, with spontaneous cure after a single eruption. To communicate a series of cases of acute generalized exanthematous pustulosis. A retrospective analysis was performed on cases of acute generalized exanthematous pustulosis, observed between 1993 and 2006 at the Dermatology Department, Hospital General de Occidente, Jalisco, Mexico. Twelve patients were included, with a predominance of male patients and a mean age of 28 years. The most common cause was drugs, detected in 83% of cases, and most of these were a result of anticonvulsants and antimicobials. The most frequent symptoms were itching, present in all cases, and fever, present in 92% of cases. Acute generalized exanthematous pustulosis is considered to be a distinct clinical and histopathologic entity. Because of its self-resolving character, early recognition can help to avoid unnecessary diagnostic studies and treatments.
              Article 0 comments Cited 10 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Rikke M. Nielsen:
                ORCID: https://orcid.org/0000-0002-5675-996X
                Rikke.maria.nielsen2@rsyd.dk
                Journal
                Journal ID (nlm-ta): Clin Case Rep
                Journal ID (iso-abbrev): Clin Case Rep
                Journal ID (doi): 10.1002/(ISSN)2050-0904
                Journal ID (publisher-id): CCR3
                Title: Clinical Case Reports
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Electronic): 2050-0904
                Publication date (Electronic): 14 February 2020
                Publication date Collection: March 2020
                Volume: 8
                Issue: 3 ( doiID: 10.1002/ccr3.v8.3 )
                Pages: 538-539
                Affiliations
                [ 1 ] Department of Dermatology and Allergy Centre Odense University Hospital Odense Denmark
                Author notes
                [*] [* ] Correspondence

                Rikke M. Nielsen, Department of Dermatology and Allergy Centre, Odense University Hospital, Kløvervænget 15, 5000 Odense, Denmark.

                Email: Rikke.maria.nielsen2@ 123456rsyd.dk

                Author information
                https://orcid.org/0000-0002-5675-996X
                Article
                Publisher ID: CCR32681
                DOI: 10.1002/ccr3.2681
                PMC ID: 7069872
                SO-VID: ebfa187e-49de-4256-8353-98a2b2014f3b
                Copyright © © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 25 October 2019
                Date revision received : 28 November 2019
                Date accepted : 05 December 2019
                Page count
                Figures: 2, Tables: 0, Pages: 2, Words: 1019
                Categories
                Subject: Case Report
                Subject: Case Reports
                Custom metadata
                source-schema-version-number 2.0
                cover-date March 2020
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:5.7.7 mode:remove_FC converted:13.03.2020

                Keywords: acute generalized exanthematous pustulosis,photoinduced acute exanthematous pustulosis
                Data availability:
                Keywords: acute generalized exanthematous pustulosis, photoinduced acute exanthematous pustulosis

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