Tumor necrosis factor-alpha G-238A polymorphism and coronary artery disease risk: a meta-analysis of 4,222 patients and 4,832 controls

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background

The aim of the present study was to investigate the association between tumor necrosis factor-alpha (TNF-α) gene G-238A polymorphism and risk of coronary artery disease (CAD) using a meta-analytical approach.

Methods

The PubMed and Embase databases were searched for relevant publications up to January 13, 2015. Four authors (XPH, XDZ, XTZ, and ZJZ) independently selected the studies, extracted, and analyzed the data using the Comprehensive Meta-Analysis software. The sensitivity and subgroups analyses were also performed. Either a fixed effects or a random effects model was used to estimate pooled odds ratios (ORs) and their 95% confidence intervals (CIs).

Results

Finally, ten articles including eleven case-control studies involving 4,222 patients and 4,832 controls were yielded. The results indicated no significant association between G-238A polymorphism and CAD risk (A vs G: OR =1.08, 95% CI =0.89–1.30; AA vs GG: OR =1.15, 95% CI =0.59–2.25; GA vs GG: OR =1.14, 95% CI =0.88–1.48; AA vs [GG + GA]: OR =1.09, 95% CI =0.56–2.14; (GA + AA) vs GG: OR =1.11, 95% CI =0.90–1.38). In the subgroup analyses, similar results were obtained with overall populations. The sensitivity analyses showed that the overall results were robust. No publication bias was detected.

Conclusion

Based on current evidence, we can conclude that TNF-α G-238A polymorphism might not be associated with CAD risk.

Most cited references 45

Record: found
Abstract: not found
Article: not found

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

David Moher, Alessandro Liberati, Jennifer Tetzlaff … (2009)

0 comments Cited 7347 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Cardiovascular disease epidemiology in Asia: an overview.

Tetsuya Ohira, Hiroyasu Iso (2013)

Cardiovascular disease (CVD) is the leading cause of death in the world and half of the cases of CVD are estimated to occur in Asia. Compared with Western countries, most Asian countries, except for Japan, South Korea, Singapore and Thailand, have higher age-adjusted mortality from CVD. In Japan, the mortality from CVD, especially stroke, has declined continuously from the 1960s to the 2000s, which has contributed to making Japan into the top-ranking country for longevity in the world. Hypertension and smoking are the most notable risk factors for stroke and coronary artery disease, whereas dyslipidemia and diabetes mellitus are risk factors for ischemic heart disease and ischemic stroke. The nationwide approach to hypertension prevention and control has contributed to a substantial decline in stroke mortality in Japan. Recent antismoking campaigns have contributed to a decline in the smoking rate among men. Conversely, the prevalence of dyslipidemia and diabetes mellitus increased from the 1980s to the 2000s and, therefore, the population-attributable risks of CVD for dyslipidemia and diabetes mellitus have increased moderately. To prevent future CVD in Asia, the intensive prevention programs for hypertension and smoking should be continued and that for emerging metabolic risk factors should be intensified in Japan. The successful intervention programs in Japan can be applied to other Asian countries.

0 comments Cited 75 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Periodontal disease and risk of coronary heart disease: An updated meta-analysis of prospective cohort studies.

Wei-Dong Leng, Xian-Tao Zeng, Joey S W Kwong … (2015)

0 comments Cited 46 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): Ther Clin Risk Manag

Journal ID (iso-abbrev): Ther Clin Risk Manag

Journal ID (publisher-id): Therapeutics and Clinical Risk Management

Title: Therapeutics and Clinical Risk Management

Publisher: Dove Medical Press

ISSN (Print): 1176-6336

ISSN (Electronic): 1178-203X

Publication date Collection: 2015

Publication date (Electronic): 23 September 2015

Volume: 11

Pages: 1429-1436

Affiliations

[1 ]Department of Cardiology, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei Province, People’s Republic of China

[2 ]Department of Cardiology and 4th Cadres Ward, General Hospital of Beijing Military Command, Beijing, People’s Republic of China

[3 ]Chinese Evidence-Based Medicine Center and Chinese Cochrane Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China

[4 ]Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University, Wuhan, People’s Republic of China

Author notes

Correspondence: Wan-Lin Wei, Department of Cardiology and 4th Cadres Ward, General Hospital of Beijing Military Command, No 5 Nan Men Cang, Dongcheng, Beijing 100125, People’s Republic of China, Tel +86 10 8400 8479, Email weiwanlin2012@ 123456126.com

[*]

These authors contributed equally to this work

Article

Publisher ID: tcrm-11-1429

DOI: 10.2147/TCRM.S87598

PMC ID: 4590639

PubMed ID: 26445542

SO-VID: 26cf480d-408a-47da-beb1-6d5d5fcaf79d

License:

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.