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      Association of Respiratory Allergy, Asthma and Expression of the SARS-CoV-2 Receptor, ACE2

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          Abstract

          Underlying respiratory allergy and experimental allergen exposure reduce the expression of the SARS-CoV-2 receptor, ACE2, which could lead to reduced COVID-19 susceptibility.

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          Author and article information

          Contributors
          Journal
          J Allergy Clin Immunol
          J. Allergy Clin. Immunol
          The Journal of Allergy and Clinical Immunology
          Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.
          0091-6749
          1097-6825
          22 April 2020
          22 April 2020
          Affiliations
          [1 ]University of Wisconsin School of Medicine and Public Health
          [2 ]Washington University School of Medicine
          [3 ]Columbia University College of Physicians and Surgeons
          [4 ]Boston University School of Medicine
          [5 ]Johns Hopkins University School of Medicine
          [6 ]Rho, Inc
          [7 ]MRC and Asthma UK, Centre in Allergic Mechanisms of Asthma
          [8 ]The Immune Tolerance Network
          [9 ]University of Chicago
          [10 ]The National Institute of Allergy and Infectious Disease
          [11 ]Department of Medicine, University of Washington
          [12 ]Benaroya Research Institute, Systems Immunology Division
          Author notes
          []Corresponding Author: Daniel J. Jackson, MD Associate Professor of Pediatrics and Medicine University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, CSC K4/936, Phone: 608-263-7686, Fax: 608-265-2207 djj@ 123456medicine.wisc.edu
          Article
          S0091-6749(20)30551-0
          10.1016/j.jaci.2020.04.009
          7175851
          c3ed4593-1f55-429b-a0a6-efb86c370434
          © 2020 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.

          Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

          History
          : 7 April 2020
          : 15 April 2020
          : 16 April 2020
          Categories
          Article

          Immunology
          sars-cov-2,covid-19,asthma,respiratory allergy,allergic sensitization,receptor,ace2 expression
          Immunology
          sars-cov-2, covid-19, asthma, respiratory allergy, allergic sensitization, receptor, ace2 expression

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