Scopariusols L-T, nine new ent -kaurane diterpenoids isolated from Isodon scoparius

Abstract

Nine new ent -kaurane diterpenoids, named scopariusols L–T ( 1–9 ), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC 50 value of 0.6 μmol·L –1 .