LncRNA KCNQ1OT1 contributes to the progression and chemoresistance in acute myeloid leukemia by modulating Tspan3 through suppressing miR-193a-3p.

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Abstract

Acute myeloid leukemia (AML) is an aggressive cancer that invariably produces drug resistance after treatment. The aim is to explore the role of lncRNA potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1) and associated novel mechanisms in the progression and chemoresistance of AML.

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Author and article information

Journal

Journal ID (iso-abbrev): Life Sci.

Title: Life sciences

Publisher: Elsevier BV

ISSN (Electronic): 1879-0631

ISSN (Print): 0024-3205

Publication date (Electronic): Jan 15 2020

Volume: 241

Affiliations

[1 ] Department of Pediatrics, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China. Electronic address: iaominglanzaehj@163.com.

[2 ] Department of Pediatrics, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.

Article

Publisher Item ID: S0024-3205(19)31089-6

DOI: 10.1016/j.lfs.2019.117161

PubMed ID: 31837329

SO-VID: f05720fc-9cfb-4c2d-97f3-ff93cb1634ef

History

Keywords: miR-193a-3p,Tspan3,KCNQ1OT1,AML,ADR

Data availability:

Keywords: miR-193a-3p, Tspan3, KCNQ1OT1, AML, ADR

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