There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Glomerulonephritis is a significant factor fueling the rapid increase in the population
of patients with end-stage renal disease. Novel therapeutic strategies targeting specific
mechanisms of glomerular destruction are the most reasonable approaches to arrest
ongoing injury. In this review, we summarize some of our results obtained in our effort
to characterize the role of 15-lipoxygenase activation as one of the mechansisms operative
during the early, prefibrotic stage of glomerular immune injury. We also summarize
the effects of cytokines released during these processes, as well as the activation
by aspirin of the synthesis of 15-R-HETE (see text). Finally, we will propose a clinical
approach to this group of disorders, based on emerging concepts of the pathophysiology
of glomerulonephritis from our work and that of several other investigators.