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Abstract
Mangosteen ( Garcinia mangostana Linn.) is a well-known tropical tree indigenous
to Southeast Asia. Its fruit’s pericarp abounds with a class of isoprenylated xanthones
which are referred as mangostins. Numerous in vitro and in vivo studies have shown
that mangostins and their derivatives possess diverse pharmacological activities,
such as antibacterial, antifungal, antimalarial, anticarcinogenic, antiatherogenic
activities as well as neuroprotective properties in Alzheimer’s disease (AD). This
review article provides a comprehensive review of the pharmacological activities of
mangostins and their derivatives to reveal their promising utilities in the treatment
of certain important diseases, mainly focusing on the discussions of the underlying
molecular targets/pathways, modes of action, and relevant structure-activity relationships
(SARs). Meanwhile, the pharmacokinetics (PK) profile and recent toxicological studies
of mangostins are also described for further druggability exploration in the future.
Author and article information
Journal
Title:
Chinese Journal of Natural Medicines
Abbreviated Title:
Chinese Journal of Natural Medicines