METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance.

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Abstract

N6-methyladenosine (m6A) RNA methylation and its associated methyltransferase METTL3 are involved in tumour initiation and progression via the regulation of RNA function. This study explored the biological function and clinical significance of METTL3 in gastric cancer (GC).

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Author and article information

Journal

Journal ID (iso-abbrev): Gut

Title: Gut

Publisher: BMJ

ISSN (Electronic): 1468-3288

ISSN (Print): 0017-5749

Publication date (Electronic): July 2020

Volume: 69

Issue: 7

Affiliations

[1 ] Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, People's Republic of China.

[2 ] Department of Molecular Cell Biology and Toxicology, Jiangsu Key Lab of Cancer Biomarkers, Prevention & Treatment, Cancer Center; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.

[3 ] Department of Geriatric Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.

[4 ] Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, People's Republic of China.

[5 ] Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, People's Republic of China.

[6 ] Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, People's Republic of China sywang@nju.edu.cn sunbc@njmu.edu.cn 13770771661@163.com.

[7 ] Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, People's Republic of China sywang@nju.edu.cn sunbc@njmu.edu.cn 13770771661@163.com.

[8 ] Center for Public Health Research, Medical School of Nanjing University, Nanjing, Jiangsu Province, People's Republic of China.

[9 ] Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, Jiangsu Province, People's Republic of China.

Article

Publisher Item ID: gutjnl-2019-319639

DOI: 10.1136/gutjnl-2019-319639

PubMed ID: 31582403

SO-VID: 788e3483-a5a1-4a1c-a5bd-091fa10b222a

History

Keywords: METTL3,angiogenesis,gastric cancer,glycolysis,m6A

Data availability:

Keywords: METTL3, angiogenesis, gastric cancer, glycolysis, m6A

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