Association between hypercortisolaemia and adipose tissue blood flow in vivo.

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Abstract

An apple-shaped fat distribution is associated with an adverse cardiometabolic phenotype. Hypercortisolaemia (Cushing's syndrome) is characterised by abdominal fat accumulation and gluteofemoral fat loss. The mechanisms underpinning this redistribution of fat mass are unknown. Since adipose tissue blood flow (ATBF) is an important determinant of lipolytic rate in vivo, we hypothesised that hypercortisolaemia might lead to differential abdominal and femoral ATBF.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Feb 26 2015

Volume: 385 Suppl 1

Affiliations

[1 ] Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK. Electronic address: k.manolopoulos@bham.ac.uk.

[2 ] Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

[3 ] Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK.

[4 ] Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.

Article

Publisher Item ID: S0140-6736(15)60378-6

DOI: 10.1016/S0140-6736(15)60378-6

PubMed ID: 26312885

SO-VID: c81cdc4b-4c0a-4ed6-b2f6-fc111f0c582d

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