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      Positive regulation of placentation by L-amino acid transporter-1 (lat1) in pregnant mice


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          Placenta plays multi-functions in embryo-uterine dialogue through facilitating gas and nutrient exchange, providing an immunological barrier between the fetus and mother and secreting hormones and growth factors to regulate pregnancy. The successful formation and development of placenta requires invasion and differentiation of trophoblast cells, and any defects would result pregnancy related diseases such as intrauterine growth retardation (IUGR), preeclampsia (PE). Lat1 (L-type amino acids transporter 1) is a major Na + independent transporter of large neutral amino acids, including several essential amino acids. It has been showed that amino acid was fundamental regulator on cell function and energy metabolism in early embryonic development. It has been reported that Lat1 mRNA expressed in zygote, blastocyst during the pre-implantation stages and trophoblast giant cells (TGCs) in post-implantation placenta in mouse. Little is known the role of lat1 on placentation. Our research was to explore the effects of lat1 on the placentation in mouse. The expression of lat1 was detected from day 9 to 18 of pregnancy in placenta. The effects of lat1 on placentation were assessed with inhibitor of leucine transport 2-aminobicyclo-(2, 2, 1)-haptane-2-carboxylic acid (BCH) treatment by uterine horns injection on day 8 (D8) of pregnancy. The protein of lat1 was mainly localized in the cytoplasm of maternal decidual cell, spongiotro-phoblast cell (Sp) and labyrinth (Lab). Inhibition of lat1 transportation activity by uterine horns injection with BCH in vivo results in disorder of placental anatomical structure in mid-late pregnancy. These results suggest that lat1 might play an important role in mouse placentation progress.

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          Author and article information

          Int J Clin Exp Pathol
          Int J Clin Exp Pathol
          International Journal of Clinical and Experimental Pathology
          e-Century Publishing Corporation
          01 September 2017
          : 10
          : 9
          : 9551-9558
          [1 ] Laboratory Animal Center, Chongqing Medical University Chongqing, China
          [2 ] Stomatological Hospital of Chongqing Medical University Chongqing, China
          [3 ] Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing, China
          [4 ] Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing, China
          [5 ] Key Laboratory of Family Planning and Health Birth, National Health and Family Planning Commission, Hebei Research Institute for Family Planning Shijiazhuang, China
          Author notes
          Address correspondence to: Jing Ma, Key Laboratory of Family Planning and Health Birth, National Health and Family Planning Commission, Hebei Research Institute for Family Planning, Shijiazhuang 050071, Hebei, China. Tel: +86-311-87041896; Fax: +86-311-87046164; E-mail: mj5658700@ 123456126.com
          PMC6965931 PMC6965931 6965931
          IJCEP Copyright © 2017
          : 10 October 2016
          : 27 November 2016
          Original Article

          mice,L-amino acid transporter-1 (lat1),Placenta
          mice, L-amino acid transporter-1 (lat1), Placenta


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