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      The new genetics of intelligence

      research-article
      1 , 2
      Nature reviews. Genetics

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          Abstract

          Intelligence — the ability to learn, reason and solve problems — is at the forefront of behavioural genetic research. Intelligence is highly heritable and predicts important educational, occupational and health outcomes better than any other trait. Recent genome-wide association studies have successfully identified inherited genome sequence differences that account for 20% of the 50% heritability of intelligence. These findings open new avenues for research into the causes and consequences of intelligence using genome-wide polygenic scores that aggregate the effects of thousands of genetic variants. In this Review, we highlight the latest innovations and insights from the genetics of intelligence and their applications and implications for science and society.

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          Most cited references47

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          GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.

          A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.
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            Why g matters: The complexity of everyday life

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              Intelligence and socioeconomic success: A meta-analytic review of longitudinal research

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                Author and article information

                Journal
                100962779
                22269
                Nat Rev Genet
                Nat. Rev. Genet.
                Nature reviews. Genetics
                1471-0056
                1471-0064
                23 May 2018
                08 January 2018
                March 2018
                01 September 2018
                : 19
                : 3
                : 148-159
                Affiliations
                [1 ]Institute of Psychiatry, Psychology and Neuroscience, King’s College London, 16 De Crespigny Park, London SE5 8AF, UK
                [2 ]Department of Psychological and Behavioural Science, London School of Economics and Political Science, Queens House, 55/56 Lincoln’s Inn Fields, London WC2A 3LJ, UK
                Article
                PMC5985927 PMC5985927 5985927 ems77908
                10.1038/nrg.2017.104
                5985927
                29335645
                11b09717-8a8e-4c0e-8029-0616aedbcb18
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