For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
33
views
12
references
 Top references
cited by
6
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      184
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Thrombotic Thrombocytopenic Purpura in a Case of Dengue Fever: A Rare Presentation.

      Read this article at

      ScienceOpenPublisherPMC
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Here, we present an unusual occurrence of thrombotic thrombocytopenic purpura (TTP) in a case of dengue fever. Both the conditions are fatal and can result in significant mortality and morbidity if left untreated. In this case, as soon as, we diagnosed the patient as having TTP, we treated her with plasma exchange therapy, steroids, and monoclonal antibodies such as rituximab. The patient responded very well to the treatment and completely recovered from neurological symptoms and laboratory parameters also normalized. Hence, timely diagnosis and starting appropriate treatment immediately are key factors for successful outcome.

          Related collections

          Most cited references12

          • Record: found
          • Abstract: found
          • Article: not found

          Dengue and dengue haemorrhagic fever.

          J G Rigau-Pérez, G G Clark, D J Gubler … (1998)
          The incidence and geographical distribution of dengue have greatly increased in recent years. Dengue is an acute mosquito-transmitted viral disease characterised by fever, headache, muscle and joint pains, rash, nausea, and vomiting. Some infections result in dengue haemorrhagic fever (DHF), a syndrome that in its most severe form can threaten the patient's life, primarily through increased vascular permeability and shock. The case fatality rate in patients with dengue shock syndrome can be as high as 44%. For decades, two distinct hypotheses to explain the mechanism of DHF have been debated-secondary infection or viral virulence. However, a combination of both now seems to be the plausible explanation. The geographical expansion of DHF presents the need for well-documented clinical, epidemiological, and virological descriptions of the syndrome in the Americas. Biological and social research are essential to develop effective mosquito control, medications to reduce capillary leakage, and a safe tetravalent vaccine.
          Article 0 comments Cited 152 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Dengue: an update.

            María G Guzmán, Gustavo Kouri (2002)
            This review is an update of dengue and dengue haemorrhagic fever (DHF) based on international and Cuban experience. We describe the virus characteristics and risk factors for dengue and DHF, and compare incidence and the case fatality rates in endemic regions (southeast Asia, western Pacific, and the Americas). The clinical picture and the pathogenesis of the severe disease are explained. We also discuss the viral, individual, and environmental factors that determine severe disease. Much more research is necessary to clarify these mechanisms. Also reviewed are methods for viral isolation and the serological, immunohistochemical, and molecular methods applied in the diagnosis of the disease. We describe the status of vaccine development and emphasise that the only alternative that we have today to control the disease is through control of its vector Aedes aegypti.
            Article 0 comments Cited 99 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Severe dengue virus infection in travelers: risk factors and laboratory indicators.

              Ole Wichmann, Joaquim Gascon, Mirjam Schunk … (2007)
              Dengue fever is the most common arboviral disease in travelers. In countries where dengue virus is endemic, sequential (secondary) infections with different dengue virus serotypes are associated with disease severity. Data on severity and secondary infection rates in a population of travelers are lacking. Intensified surveillance of dengue fever in travelers was performed within the European Network on Surveillance of Imported Infectious Diseases. Data were collected at 14 European clinical referral centers between 2003 and 2005. A total of 219 dengue virus infections imported from various regions of endemicity were reported. Serological analysis revealed a secondary immune response in 17%. Spontaneous bleeding was observed in 17 (8%) patients and was associated with increased serum alanine and aspartate aminotransferase levels and lower median platelet counts. Two (0.9%) patients fulfilled the World Health Organization (WHO) case definition for dengue hemorrhagic fever. However, 23 (11%) travelers had severe clinical manifestations (internal hemorrhage, plasma leakage, shock, or marked thrombocytopenia). A secondary immune response was significantly associated with both spontaneous bleeding and other severe clinical manifestations. In travelers, severe dengue virus infections are not uncommon but may be missed if the WHO classification is strictly applied. High liver enzyme levels and low platelet counts could serve as indicators of disease severity.
              Article 0 comments Cited 41 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (iso-abbrev): Indian J Crit Care Med
                Title: Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
                Publisher: Medknow
                ISSN: 0972-5229
                ISSN (Print): 0972-5229
                Publication date (Electronic): Apr 2017
                Volume: 21
                Issue: 4
                Affiliations
                [1 ] Department of Critical Care Medicine, Aditya Birla Memorial Hospital, Pune, Maharashtra, India.
                [2 ] Department of Hematology, Aditya Birla Memorial Hospital, Pune, Maharashtra, India.
                Article
                Publisher Item ID: IJCCM-21-226
                DOI: 10.4103/ijccm.IJCCM_27_16
                PMC ID: 5416791
                PubMed ID: 28515608
                SO-VID: 902722da-9ddd-47d5-b1f6-a9cde279b0a2
                History

                Keywords: ADAMTS13,dengue fever,plasma exchange therapy,rare case presentation,thrombotic thrombocytopenic purpura
                Data availability:
                Keywords: ADAMTS13, dengue fever, plasma exchange therapy, rare case presentation, thrombotic thrombocytopenic purpura

                Comments

                Comment on this article

                scite_

                Similar content184

                See all similar

                Cited by6

                See all cited by

                Most referenced authors209

                See all reference authors