Evaluation of analgesic, antipyretic and anti-inflammatory activity on Cordia dichotoma G. Forst. Leaf.

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Abstract

Cordia dichotoma G. Forst. is an important medicinal plant of family Boraginaceae. Traditionally, its leaves are used to treat fever, headache, and joint pain but its medicinal activities have not been proven by research.

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Most cited references 17

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Phytochemical Methods

J. Harborne, J. HARBORNE, JB Harborne … (1973)

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Trease and Evan›s Pharmacognosy

WC EVANS, WC Evans, G Trease … (1996)

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Anticonvulsant, analgesic and antipyretic activities of Taxus wallichiana Zucc.

Obaidullah Ashraf, Humera Perveen, Inamullah Khan … (2008)

Taxus wallichiana Zucc. (Himalayan Yew) is often used in northern areas of Pakistan for the treatment of pyrexia, acute pains and epilepsy. We have investigated certain pharmacological activities of the methanol leaf extract against convulsion, nociception and pyrexia induced in rodents. The aim was to justify and explore its folk uses in these pathological conditions, on scientific basis. The studies were carried out using acetic acid-induced nociception and pentylenetetrazole-induced convulsions in mice, while formalin test and yeast-induced pyrexia in rats. Significant analgesic (67.77 and 74.29%) effect was found in acetic acid-induced model at doses of 100 and 200mg/kg, i.p. respectively. Crude extract exhibited significant (P<0.05) inhibition of the formalin noxious stimulation on both early and late phases of pain by the extracts (100 and 200mg/kg doses). In case of yeast-induced pyrexia model, 200mg/kg dose showed very significant (P<0.01) inhibition while 50 and 100mg/kg dose caused a significant (P<0.05) inhibition. Plant extract has controlled the pentylenetetrazole-induced convulsions in mice. 100 and 200mg/kg i.p doses of the extract significantly (P<0.05) inhibited the mioclonus and clonus while inhibition of tonus and hind limb tonic extension (HLTE) was highly significant (P<0.01). The anticonvulsant activity of this plant has been reported for the first time throughout the whole genus. The observed pharmacological activities provide the scientific basis for the folkloric use of the plant in treating epilepsy, pyrexia and acute pain.

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Journal

Journal ID (iso-abbrev): Pharmacognosy Res

Title: Pharmacognosy research

Publisher: Medknow

ISSN: 0976-4836

ISSN (Print): 0974-8490

Publication date (Electronic): January 20 2015

Volume: 7

Issue: 1

Affiliations

[1 ] Department of Pharmacognosy, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela (Ropar), Punjab, India.

Article

Publisher Item ID: PR-7-126

DOI: 10.4103/0974-8490.147227

PMC ID: 4285642

PubMed ID: 25598647

SO-VID: 06ae04c2-1eb5-4e4e-a372-1aa85db4432c

History

Keywords: Analgesic,Boraginaceae,Cordia dichotoma,anti-inflammatory,antipyretic

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Keywords: Analgesic, Boraginaceae, Cordia dichotoma, anti-inflammatory, antipyretic

Evaluation of analgesic, antipyretic and anti-inflammatory activity on Cordia dichotoma G. Forst. Leaf.

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Most cited references 17

Phytochemical Methods

Trease and Evan›s Pharmacognosy

Anticonvulsant, analgesic and antipyretic activities of Taxus wallichiana Zucc.

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Affiliations

Article

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