Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin: a subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial.

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Abstract

Ticagrelor is an effective antiplatelet therapy for patients with coronary atherosclerotic disease and might be more effective than aspirin in preventing recurrent stroke and cardiovascular events in patients with acute cerebral ischaemia of atherosclerotic origin. Our aim was to test for a treatment-by-ipsilateral atherosclerotic stenosis interaction in a subgroup analysis of patients in the Acute Stroke or Transient Ischaemic Attack Treated with Aspirin or Ticagrelor and Patient Outcomes (SOCRATES) trial.

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Journal

Journal ID (iso-abbrev): Lancet Neurol

Title: The Lancet. Neurology

Publisher: Elsevier BV

ISSN (Electronic): 1474-4465

ISSN (Print): 1474-4422

Publication date (Electronic): Feb 23 2017

Affiliations

[1 ] Department of Neurology and Stroke Center, Bichat University Hospital and Paris-Diderot, Sorbonne University, Paris, France. Electronic address: pierre.amarenco@aphp.fr.

[2 ] Stanford University Medical Center, Stanford Stroke Center, Palo Alto, CA, USA.

[3 ] AstraZeneca, Gothenburg, Sweden.

[4 ] Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

[5 ] Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

[6 ] Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.

[7 ] Department of Neurology, Perelman School of Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA.

[8 ] National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.

[9 ] Stroke Unit, Hospital Vall d'Hebron, Barcelona, Spain.

[10 ] Department of Neurology, Tiantan Hospital, Beijing, China.

[11 ] Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.

[12 ] Dell Medical School, University of Texas, Austin, TX, USA.

Article

Publisher Item ID: S1474-4422(17)30038-8

DOI: 10.1016/S1474-4422(17)30038-8

PubMed ID: 28238711

SO-VID: 7e123303-d252-43d2-8535-aeefcae8b76b

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