Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial.

Munne, Santiago; Kaplan, Brian; Frattarelli, John L; Child, Tim; Nakhuda, Gary S; Shamma, F Nicholas; Silverberg, Kaylen M; Kalista, Tasha; Handyside, Alan H.; Katz-Jaffe, Mandy G.; Wells, Dagan; Gordon, Tony; Stock-Myer, Sharyn E.; Willman, Susan; Acacio, Brian A; Lavery, Stuart; Carby, Anna; Boostanfar, Robert; Forman, Robert F.; Sedler, Mark J.; Jackson, Anthea; Jordan, Keith; Schoolcraft, William B.; McReynolds, Susanna; Schnell, Vicki L; Loy, Randall A.; Chantilis, Samuel J; Ku, Lowell; Morales, Arlene J.; Craig, H. Randall; Perloe, Mark; Witz, Craig; Wang, Wei-Hua; Wilcox, John; Norian, John M; Thompson, Stephanie Marshall; Chen, Serena; Garrisi, John; Walmsley, Renee; Mendola, Robert; Pang, Samuel; Sakkas, Denny; Rooney, Kristin E; Sneeringer, Rita; Glassner, Michael; Wilton, Leeanda; Martic, Mirjana; Coleman, Peter Francis; Shepley, Stephanie; Mounce, Ginny; Griffiths, Tracey; Feinberg, Ronald F.; Blauer, Keith L.; Reggio, Brett; Rhinehart, Rachel; Ziegler, William; Ahmed, Hina; Kratka, Scott; Rosenbluth, Evan M; Ivani, Kristen; Thyer, Angela; Minter, Tamara; Miller, Charles; Gysler, Mathias; Saunders, Pauline; Casper, Robert F.; Conway, Deirdre; Hughes, Mark; Large, Michael C; Blazek, Joshua D; Fragouli, Elpida; Alfarawati, Samer

doi:10.1016/j.fertnstert.2019.07.1346

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Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial.

Author(s): Santiago Munné ¹ , Brian Kaplan ² , John L Frattarelli ³ , Tim Child ⁴ , Gary Nakhuda ⁵ , F Nicholas Shamma ⁶ , Kaylen Silverberg ⁷ , Tasha Kalista ⁸ , Alan H Handyside ⁹ , Mandy Katz-Jaffe ¹⁰ , Dagan Wells ¹¹ , Tony Gordon ¹² , Sharyn Stock-Myer ¹³ , Susan Willman ¹⁴

Publication date (Electronic): December 2019

Journal: Fertility and sterility

Publisher: Elsevier BV

Keywords: IVF, frozen-thawed embryo transfer, next-generation sequencing, preimplantation genetic testing, single-embryo transfer

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Abstract

To evaluate the benefit of next-generation sequencing (NGS)-based preimplantation genetic testing for aneuploidy (PGT-A) for embryo selection in frozen-thawed embryo transfer.

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Journal ID (iso-abbrev): Fertil Steril

Title: Fertility and sterility

Publisher: Elsevier BV

ISSN (Electronic): 1556-5653

ISSN (Print): 0015-0282

Publication date (Electronic): December 2019

Volume: 112

Issue: 6

Affiliations

[1 ] Cooper Genomics, Livingston, New Jersey; Department of Obstetrics, Gynecology, and Reproductive Science, Yale University, New Haven, Connecticut.

[2 ] Highland Park IVF Center, Fertility Centers of Illinois, Highland Park, Illinois.

[3 ] Fertility Institute of Hawaii, Honolulu, Hawaii.

[4 ] Oxford Fertility, Oxford, United Kingdom.

[5 ] Olive Fertility Center, Vancouver, British Columbia, Canada.

[6 ] IVF Michigan, Bloomfield Hills, Michigan.

[7 ] Texas Fertility Center, Austin, Texas; Ovation Fertility, Los Angeles, California.

[8 ] Illumina, Foster City, California.

[9 ] School of Biosciences, University of Kent, Canterbury, United Kingdom.

[10 ] Colorado Center for Reproductive Medicine, Lone Tree, Colorado.

[11 ] Reprogenetics, Oxford, United Kingdom.

[12 ] Cooper Genomics, London, United Kingdom.

[13 ] Melbourne IVF, Melbourne, Victoria, Australia.

[14 ] Reproductive Science Center, San Ramon, California. Electronic address: susan@susanwillman.com.

Article

Publisher Item ID: S0015-0282(19)31979-X

DOI: 10.1016/j.fertnstert.2019.07.1346

PubMed ID: 31551155

SO-VID: fa54da5a-64c3-439c-9eae-f99ef921ae83

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Keywords: IVF,frozen-thawed embryo transfer,next-generation sequencing,preimplantation genetic testing,single-embryo transfer

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Keywords: IVF, frozen-thawed embryo transfer, next-generation sequencing, preimplantation genetic testing, single-embryo transfer

Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial.

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