Tianma Formula Alleviates Dementia via ACER2-Mediated Sphingolipid Signaling Pathway Involving Aβ.

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Abstract

To reveal the molecular mechanism of the antagonistic effect of traditional Chinese medicine Tianma formula (TF) on dementia including vascular dementia (VaD) and Alzheimer's disease (AD) and to provide a scientific basis for the study of traditional Chinese medicine for prevention and treatment of dementia.

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Journal

Journal ID (iso-abbrev): Evid Based Complement Alternat Med

Title: Evidence-based complementary and alternative medicine : eCAM

Publisher: Hindawi Limited

ISSN: 1741-427X

ISSN (Print): 1741-427X

Publication date (Electronic): 2021

Volume: 2021

Affiliations

[1 ] School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China.

[2 ] Zhaotong Institute of Tianma, Zhaotong 657000, China.

[3 ] Kunming Institute of Medical Sciences, Kunming 650011, China.

[4 ] College of Agronomy and Life Sciences, Zhaotong University, Zhaotong 657000, China.

[5 ] Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

[6 ] Department of Cardiovascular Surgery, The 1st Affiliated Hospital of Kunming Medical University, Kunmin 650032, China.

Article

DOI: 10.1155/2021/6029237

PMC ID: 8357478

PubMed ID: 35069753

SO-VID: 00523b61-436c-404e-a668-97032a2a5dd5

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