Contributors
Keisho Hirota: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: VisualizationRole: Writing – original draftRole: Writing – review &
editing
Mayumi Furuya: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole:
Writing – original draftRole: Writing – review & editing
Naomi Morozumi: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: ValidationRole: Writing – review & editing
Kazunori Yoshikiyo: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
SoftwareRole: ValidationRole: VisualizationRole: Writing – original draftRole: Writing
– review & editing
Takafumi Yotsumoto: Role: Data curationRole: Formal analysisRole: MethodologyRole: ValidationRole: Writing
– review & editing
Toshimasa Jindo: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: ValidationRole: VisualizationRole: Writing – review & editing
Ryuichi Nakamura: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: ValidationRole: Writing – review & editing
Koichiro Murakami: Role: Formal analysisRole: InvestigationRole: Methodology
Yohei Ueda: Role: Data curationRole: Formal analysisRole: MethodologyRole: ResourcesRole: SoftwareRole:
ValidationRole: Writing – review & editing
Takeshi Hanada: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: ValidationRole: Writing – review & editing
Hiroko Sade: Role: Data curationRole: Formal analysisRole: Methodology
Sayaka Yoshida: Role: Data curationRole: Formal analysisRole: ResourcesRole: ValidationRole: Writing
– original draftRole: Writing – review & editing
Kei Enomoto: Role: Data curationRole: SupervisionRole: Writing – review & editing
Yugo Kanai: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Resources
Ichiro Yamauchi: Role: Data curationRole: InvestigationRole: MethodologyRole: SupervisionRole: Writing
– review & editing
Takafumi Yamashita: Role: Data curationRole: Resources
Yoriko Ueda-Sakane: Role: Data curationRole: Methodology
Toshihito Fujii: Role: Formal analysisRole: InvestigationRole: Methodology
Akihiro Yasoda:
ORCID: http://orcid.org/0000-0001-8866-5303
Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: Project administrationRole:
Writing – original draftRole: Writing – review & editing
Nobuya Inagaki: Role: Funding acquisitionRole: SupervisionRole: Writing – review & editing
Dominique Heymann: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
20
September
2018
Publication date Collection: 2018
Volume: 13
Issue: 9
Electronic Location Identifier: e0204172
Affiliations
[1
]
Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School
of Medicine, Kyoto, Japan
[2
]
Asubio Pharma Co. Ltd. Kobe, Japan
[3
]
Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
Universite de Nantes, FRANCE
Author notes
Competing Interests: KH, KM, YU, YK, IY, T Yamashita, YU-S, TF, AY and NI have nothing to disclose. MF,
NM, KY, T Yotsumoto, TJ, RN, TH, HS, SY and KE were employed by Asubio Pharma Co.,
Ltd. There are no patents, products in development or marketed products to declare.
This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-18-14943
DOI: 10.1371/journal.pone.0204172
PMC ID: 6147488
PubMed ID: 30235256
SO-VID: 011026ce-e4e0-45e4-9ba7-2857fc8c4b3c
Copyright © © 2018 Hirota et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 18
May
2018
Date
accepted
: 3
September
2018
Page count
Figures: 9,
Tables: 3,
Pages: 20
Funding
Funded by: funder-id http://dx.doi.org/10.13039/501100001691, Japan Society for the Promotion of Science;
Award ID: JP 17K09881
Award Recipient
:
ORCID: http://orcid.org/0000-0001-8866-5303
Akihiro Yasoda
Funded by: funder-id http://dx.doi.org/10.13039/501100001691, Japan Society for the Promotion of Science;
Award ID: 21591176
Award Recipient
:
ORCID: http://orcid.org/0000-0001-8866-5303
Akihiro Yasoda
Funded by: funder-id http://dx.doi.org/10.13039/100008732, Uehara Memorial Foundation;
Award Recipient
:
ORCID: http://orcid.org/0000-0001-8866-5303
Akihiro Yasoda
This work was supported by Grants-in-Aid for Scientific Research from the Ministry
of Education, Culture, Sports, Science and Technology of Japan (21591176 and JP 17K09881),
and the Uehara Memorial Foundation. Asubio Pharma Co., Ltd. provided support in the
form of salaries for authors [MF, NM, KY, TY, TJ, RN, TH, HS, SY and KE], but did
not have any additional role in the study design, data collection and analysis, decision
to publish, or preparation of the manuscript. The specific roles of these authors
are articulated in the 'author contributions' section.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Bone
Subject:
Growth Plate
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Bone
Subject:
Growth Plate
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Bone
Subject:
Growth Plate
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Bone
Subject:
Growth Plate
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Musculoskeletal System
Subject:
Skeleton
Subject:
Tibia
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Musculoskeletal System
Subject:
Skeleton
Subject:
Tibia
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Musculoskeletal System
Subject:
Skeleton
Subject:
Femur
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Musculoskeletal System
Subject:
Skeleton
Subject:
Femur
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Hormones
Subject:
Peptide Hormones
Subject:
Natriuretic Peptide
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Cartilage
Subject:
Chondrocytes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Cartilage
Subject:
Chondrocytes
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Connective Tissue Cells
Subject:
Chondrocytes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Chondrocytes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Connective Tissue Cells
Subject:
Chondrocytes
Subject:
Research and Analysis Methods
Subject:
Bioassays and Physiological Analysis
Subject:
Microarrays
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