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      • Record: found
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      Meteorological factors and risk of hemorrhagic fever with renal syndrome in Guangzhou, southern China, 2006–2015

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          Abstract

          Background

          The epidemic tendency of hemorrhagic fever with renal syndrome (HFRS) is on the rise in recent years in Guangzhou. This study aimed to explore the associations between meteorological factors and HFRS epidemic risk in Guangzhou for the period from 2006–2015.

          Methods

          We obtained data of HFRS cases in Guangzhou from the National Notifiable Disease Report System (NNDRS) during the period of 2006–2015. Meteorological data were obtained from the Guangzhou Meteorological Bureau. A negative binomial multivariable regression was used to explore the relationship between meteorological variables and HFRS.

          Results

          The annual average incidence was 0.92 per 100000, with the annual incidence ranging from 0.64/100000 in 2009 to 1.05/100000 in 2012. The monthly number of HFRS cases decreased by 5.543% (95%CI -5.564% to -5.523%) each time the temperature was increased by 1°C and the number of cases decreased by 0.075% (95%CI -0.076% to -0.074%) each time the aggregate rainfall was increased by 1 mm. We found that average temperature with a one-month lag was significantly associated with HFRS transmission.

          Conclusions

          Meteorological factors had significant association with occurrence of HFRS in Guangzhou, Southern China. This study provides preliminary information for further studies on epidemiological prediction of HFRS and for developing an early warning system.

          Author summary

          The prevalence of HFRS was on the rise in recent years, especially in the large and medium-sized cities in China. We obtained data of HFRS cases in Guangzhou from the National Notifiable Disease Report System (NNDRS) during the period of 2006–2015. Meteorological data were obtained from the Guangzhou Meteorological Bureau. A negative binomial multivariable regression was used to explore the relationship between meteorological variables and HFRS. Meteorological factors had significant association with occurrence of HFRS in Guangzhou, Southern China. This study provides preliminary information for further studies on epidemiological prediction of HFRS and for developing an early warning system.

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          Most cited references29

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          Climatic and environmental patterns associated with hantavirus pulmonary syndrome, Four Corners region, United States.

          D Engelthaler, D. G. Mosley, J. E. Cheek … (1999)
          To investigate climatic, spatial, temporal, and environmental patterns associated with hantavirus pulmonary syndrome (HPS) cases in the Four Corners region, we collected exposure site data for HPS cases that occurred in 1993 to 1995. Cases clustered seasonally and temporally by biome type and geographic location, and exposure sites were most often found in pinyon-juniper woodlands, grasslands, and Great Basin desert scrub lands, at elevations of 1,800 m to 2,500 m. Environmental factors (e.g., the dramatic increase in precipitation associated with the 1992 to 1993 El Niño) may indirectly increase the risk for Sin Nombre virus exposure and therefore may be of value in designing disease prevention campaigns.
          Article 0 comments Cited 91 times – based on 0 reviews     Review now
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            Outbreak of hantavirus infection in the Four Corners region of the United States in the wake of the 1997-1998 El Nino-southern oscillation.

            Brian Hjelle, Andrew G Glass (2000)
            Hantavirus cardiopulmonary syndrome (HCPS), a rodent-borne zoonosis, has been endemic in the Americas for at least several decades. It is hypothesized that the 1991-1992 El Niño-southern oscillation (ENSO) caused increased precipitation that allowed an increase in rodent population densities, thereby increasing the possibility of transmission to humans. The result was a 1993-1994 outbreak of the disease in the Four Corners states of the southwestern United States. A second strong ENSO occurred in 1997-1998, after a period of considerable public education about the risks of hantavirus infection that began during the 1993-1994 outbreak. The caseload of HCPS increased 5-fold above baseline in the Four Corners states in 1998-1999. Regions that had received increased rainfall in 1998 were especially affected. A large majority of the 1998-1999 case patients reported indoor exposure to deer mice. Hantavirus outbreaks can occur in response to abiotic events, even in the face of extensive public education and awareness.
            Article 0 comments Cited 66 times – based on 0 reviews     Review now
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              Epidemiology of Hantavirus infections in humans: a comprehensive, global overview.

              Dionysios Watson, Maria Sargianou, Anna Papa … (2014)
              Hantaviruses comprise an emerging global threat for public health, affecting about 30,000 humans annually. Infection may lead to Hantavirus pulmonary syndrome (HPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in the Europe and Asia. Humans are spillover hosts, acquiring infection primarily through the inhalation of aerosolized excreta from infected rodents and insectivores. Risk factors for infection include involvement in outdoor activities, such as rural- and forest-related activities, peridomestic rodent presence, exposure to potentially infected dust and outdoor military training; prolonged, intimate contact with infected individuals promotes transmission of Andes virus, the only Hantavirus known to be transmitted from human-to-human. The total number of Hantavirus case reports is generally on the rise, as is the number of affected countries. Knowledge of the geographical distribution, regional incidence and associated risk factors of the disease are crucial for clinicians to suspect and diagnose infected individuals early on. Climatic, ecological and environmental changes are related to fluctuations in rodent populations, and subsequently to human epidemics. Thus, prevention may be enhanced by host-reservoir control and human exposure prophylaxis interventions, which likely have led to a dramatic reduction of human cases in China over the past decades; vaccination may also play a role in the future.
              Article 0 comments Cited 65 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Yuehong Wei: Role: Formal analysisRole: MethodologyRole: SupervisionRole: Writing – original draft
                Yang Wang: Role: Data curationRole: SoftwareRole: Writing – original draft
                Xiaoning Li: Role: MethodologyRole: Software
                Pengzhe Qin: Role: Formal analysisRole: Writing – review & editing
                Ying Lu: Role: Formal analysisRole: Methodology
                Jianmin Xu: Role: SoftwareRole: Writing – original draft
                Shouyi Chen: Role: Supervision
                Meixia Li: Role: Formal analysisRole: SoftwareRole: Writing – review & editing
                Zhicong Yang:
                ORCID: http://orcid.org/0000-0002-5583-1536
                Role: Funding acquisitionRole: SupervisionRole: Writing – review & editing
                Claudia Munoz-Zanzi: Role: Editor
                Journal
                Journal ID (nlm-ta): PLoS Negl Trop Dis
                Journal ID (iso-abbrev): PLoS Negl Trop Dis
                Journal ID (publisher-id): plos
                Journal ID (pmc): plosntds
                Title: PLoS Neglected Tropical Diseases
                Publisher: Public Library of Science (San Francisco, CA USA )
                ISSN (Print): 1935-2727
                ISSN (Electronic): 1935-2735
                Publication date (Electronic): 27 June 2018
                Publication date Collection: June 2018
                Volume: 12
                Issue: 6
                Electronic Location Identifier: e0006604
                Affiliations
                [1 ] Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong province, China
                [2 ] The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong province, China
                University of Minnesota, UNITED STATES
                Author notes

                The authors have declared that no competing interests exist.

                Author information
                http://orcid.org/0000-0002-5583-1536
                Article
                Publisher ID: PNTD-D-17-01026
                DOI: 10.1371/journal.pntd.0006604
                PMC ID: 6039051
                PubMed ID: 29949572
                SO-VID: 0224f9e3-8759-4d86-bc90-7d24ccc1e89b
                Copyright © © 2018 Wei et al
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                Date received : 29 June 2017
                Date accepted : 11 June 2018
                Page count
                Figures: 3, Tables: 4, Pages: 11
                Funding
                Funded by: Science and Technology Plan Grant of Guangzhou
                Award ID: 201607010130
                Funded by: Natural Science Foundation of Guangdong Province
                Award ID: 2015A030313813
                Award Recipient :
                Funded by: The Project for Key Medicine Discipline Construction of Guangzhou Municipality
                Award ID: 2017-2019-07
                Award Recipient :
                ORCID: http://orcid.org/0000-0002-5583-1536
                Funded by: Medical and Health science and technology Project of Guangzhou
                Award ID: 20171A011275
                Award Recipient :
                This study was supported by Science and Technology Plan Grant of Guangzhou (201607010130), Natural Science Foundation of Guangdong Province (2015A030313813), The Project for Key Medicine Discipline Construction of Guangzhou Municipality (2017-2019-07) and Medical and Health science and technology Project of Guangzhou (20171A011275).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Subject: Research Article
                Subject: Medicine and Health Sciences
                Subject: Infectious Diseases
                Subject: Viral Diseases
                Subject: Hemorrhagic Fever with Renal Syndrome
                Subject: Earth Sciences
                Subject: Atmospheric Science
                Subject: Meteorology
                Subject: Rain
                Subject: Biology and Life Sciences
                Subject: Organisms
                Subject: Eukaryota
                Subject: Animals
                Subject: Vertebrates
                Subject: Amniotes
                Subject: Mammals
                Subject: Rodents
                Subject: Earth Sciences
                Subject: Atmospheric Science
                Subject: Meteorology
                Subject: Humidity
                Subject: Biology and Life Sciences
                Subject: Organisms
                Subject: Eukaryota
                Subject: Animals
                Subject: Invertebrates
                Subject: Arthropoda
                Subject: Mites
                Subject: Biology and life sciences
                Subject: Organisms
                Subject: Viruses
                Subject: RNA viruses
                Subject: Bunyaviruses
                Subject: Hantavirus
                Subject: Biology and Life Sciences
                Subject: Microbiology
                Subject: Medical Microbiology
                Subject: Microbial Pathogens
                Subject: Viral Pathogens
                Subject: Bunyaviruses
                Subject: Hantavirus
                Subject: Medicine and Health Sciences
                Subject: Pathology and Laboratory Medicine
                Subject: Pathogens
                Subject: Microbial Pathogens
                Subject: Viral Pathogens
                Subject: Bunyaviruses
                Subject: Hantavirus
                Subject: Biology and Life Sciences
                Subject: Organisms
                Subject: Viruses
                Subject: Viral Pathogens
                Subject: Bunyaviruses
                Subject: Hantavirus
                Subject: Medicine and Health Sciences
                Subject: Epidemiology
                Subject: People and Places
                Subject: Geographical Locations
                Subject: Asia
                Subject: China
                Custom metadata
                PLOS Publication Stage vor-update-to-uncorrected-proof
                Publication Update 2018-07-10
                Data Availability All relevant data are within the paper and its Supporting Information files.

                ScienceOpen disciplines: Infectious disease & Microbiology
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology

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