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      Chlyous leak after radical oesophagectomy: Thoracic duct lymphangiography and embolisation (TDE)—A case report

      case-report
      a , * , b , a
      International Journal of Surgery Case Reports
      Elsevier

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          Highlights

          • An unrecognised iatrogenic thoracic duct chyle leak carries significant morbidity and mortality.

          • A case of chylothorax post oesophagectomy, treated by interventional radiology, is described.

          • Lymphangiography identified aberrant thoracic ductal anatomy.

          • Coiling and embolization following ductal injury is safe, effective and less morbid procedure.

          Abstract

          Introduction

          Chyle leak after oesophagectomy is highly morbid and may carry significant mortality if treatment is delayed. Identification of the site of leakage and surgery may be plagued by failure.

          Presentation of case

          We describe a case of chyle leak after oesophagectomy. Lymphangiography revealed the site of chyle leak to be an aberrant duct that would have been difficult to identify surgically. Radiological coiling and embolization successfully treated the leak.

          Discussion

          The gold standard for treatment of chyle leak or chylothorax after oesophagectomy was a re-operation, either open or throracoscopic, to ligate the thoracic duct. The interventional radiological technique employed in our case was not only efficacious in stopping the leak, but had the added advantage of identifying the site and highlighting the anatomy hence avoiding a morbid reoperation. The literature is reviewed.

          Conclusion

          The report and review confirm that lymphangiography followed by coiling and embolization for chylothorax post oesophagectomy is safe and effective in a majority of cases.

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          Most cited references30

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          Aetiology and management of chylothorax in adults.

          Though rare in incidence, chylothorax can lead to significant morbidity and mortality. Its occurrence corresponds to increased mortality following esophagectomy. Leakage of chyle and lymph leads to significant loss of essential proteins, immunoglobulins, fat, vitamins, electrolytes and water. The presence of chylomicrons and a triglyceride level >110 mg/dl in the aspirated pleural fluid confirms the diagnosis of chylothorax. Identifying the aetiology using different diagnostic tests is important in planning treatment. While therapeutic thoracentesis provides relief from respiratory symptoms, the nutritional deficiency will continue to persist or deteriorate unless definitive therapeutic measures are instituted to stop leakage of chyle into the pleural space. Definitive therapy consists of obliteration and prevention of recurrence of chylothorax. Aggressive surgical therapy is recommended for post-traumatic or post-surgical chylothorax.
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            Nonoperative thoracic duct embolization for traumatic thoracic duct leak: experience in 109 patients.

            To demonstrate the efficacy of a minimally invasive, nonoperative, catheter-based approach to the treatment of traumatic chyle leak. A retrospective review of 109 patients was conducted to assess the efficacy of thoracic duct embolization or interruption for the treatment of high-output chyle leak caused by injury to the thoracic duct. A total of 106 patients presented with chylothorax, 1 patient presented with chylopericardium, and 2 patients presented with cervical lymphocele. Twenty patients (18%) had previous failed thoracic duct ligation. In 108 of 109 patients, a lymphangiogram was successful. Catheterization of the thoracic duct was achieved in 73 patients (67%). In 71 of these 73 patients, embolization of the thoracic duct was performed. Endovascular coils or liquid embolic agent was used to occlude the thoracic duct. In 18 of 33 cases of unsuccessful catheterization, thoracic duct needle interruption was attempted below the diaphragm. Resolution of the chyle leak was observed in 64 of 71 patients (90%) post-embolization. Needle interruption of the thoracic duct was successful in 13 of 18 patients (72%). In 17 of the 20 patients who had previous attempts at thoracic duct ligation, embolization or interruption was attempted and successful in 15 (88%). The overall success rate for the entire series was 71% (77/109). There were 3 (3%) minor complications. Catheter embolization or needle interruption of the thoracic duct is safe, feasible, and successful in eliminating a high-output chyle leak in the majority (71%) of patients. This minimally invasive, although technically challenging, procedure should be the initial approach for the treatment of a traumatic chylothorax. Published by Mosby, Inc.
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              The effectiveness of lymphangiography as a treatment method for various chyle leakages.

              The purpose of this study was to assess the effectiveness of lymphangiography as a treatment for various chyle leakages. Pedal lymphangiography was performed in 9 patients (6 men and 3 women; mean age, 59 years) who were unlikely to be cured only by conservative treatment - a low-fat medium-chain triglyceride diet, total parenteral nutrition and insertion of a drainage tube - and in whom chylothorax (n = 5), chylous ascites (n = 2) and lymphatic fistulae (n = 2) were refractory to conservative treatment. In 7 of these 9 patients (78%), we could detect the chyle leakage sites. In 8 of the 9 patients (89%), lymphatic leakage was stopped after lymphangiography, and surgical re-intervention was avoided. No cases had a recurrence of chyle leakage during follow-up (range, 1-54 months). Lymphangiography is effective not only for diagnosis but also as treatment for various chyle leakages. Early lymphangiography is therefore recommended for patients with chyle leakages who are unlikely to be cured by conservative treatment only.
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                Author and article information

                Contributors
                Journal
                Int J Surg Case Rep
                Int J Surg Case Rep
                International Journal of Surgery Case Reports
                Elsevier
                2210-2612
                07 April 2016
                2016
                07 April 2016
                : 23
                : 12-16
                Affiliations
                [a ]Department of Upper GI Surgery, Concord Repatriation General Hospital, Hospital Road, Sydney, NSW 2139, Australia
                [b ]Department of Radiology, Concord Repatriation General Hospital, Hospital Road, Sydney, NSW 2139, Australia
                Author notes
                [* ]Corresponding author. moatiemd@ 123456yahoo.com
                Article
                S2210-2612(16)30060-8
                10.1016/j.ijscr.2016.04.002
                4855420
                27082992
                02b43758-019e-4c23-9da3-f2a98846fbe4
                © 2016 The Authors

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 27 January 2016
                : 17 March 2016
                : 2 April 2016
                Categories
                Case Report

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