3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet-induced obesity and associated pathologies.

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Obesity predisposes individuals to metabolic syndrome, which increases the risk of cardiovascular diseases, non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes. A pathological manifestation of obesity is the activation of the coagulation system. In turn, extravascular fibrin(ogen) deposits accumulate in adipose tissues and liver. These deposits promote adiposity and downstream sequelae by driving pro-inflammatory macrophage function through binding the leukocyte integrin receptor αM β2 .

          Related collections

          Author and article information

          Journal
          J Thromb Haemost
          Journal of thrombosis and haemostasis : JTH
          Wiley
          1538-7836
          1538-7836
          Dec 2022
          : 20
          : 12
          Affiliations
          [1 ] Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
          [2 ] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
          [3 ] UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
          [4 ] Department of Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA.
          [5 ] Michael Smith Laboratories and Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada.
          [6 ] Blood Research Institute, Milwaukee, Wisconsin, USA.
          Article
          NIHMS1838564 S1538-7836(22)18366-2
          10.1111/jth.15877
          9669152
          36111375
          02cd410f-8d31-4564-aa95-0872bbb99f7a
          History

          obesity,fibrinogen,fatty liver disease,factor XIII,diabetes
          obesity, fibrinogen, fatty liver disease, factor XIII, diabetes

          Comments

          Comment on this article