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Abstract
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto"
id="d928999e75">The objective of the study was to investigate the association of blood
glucose and
lipid profile parameters with cognitive impairment in schizophrenia. A total of 200
schizophrenia patients and 169 controls were enrolled in the study. Blood glucose
and lipid profile were estimated in all the subjects. Cognition was assessed using
Addenbrooke cognitive examination-III (ACE-III). Fasting glucose (p ≤ .001) and triacylglycerol
(p = .018) were increased and HDL-Cholesterol (p ≤ .001), was reduced in schizophrenia.
Glucose (r = -0.158, p = .026), total cholesterol (r = -0.249, p = .0001) and triacylglycerol
(r = -0.168, p = .018) was negatively correlated with total ACE III score. Triacylglycerol
(p = .041) was elevated in cases with mild cognitive impairment. Plasma glucose, total
cholesterol and triacylglycerol were associated with various cognitive domains suggesting
that hyperglycaemia and hyperlipidaemia might increase the risk of cognitive impairment
in schizophrenia.
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