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      Catecholamines profiles at diagnosis: Increased diagnostic sensitivity and correlation with biological and clinical features in neuroblastoma patients.

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          Abstract

          Neuroblastoma (NBL) accounts for 10% of the paediatric malignancies and is responsible for 15% of the paediatric cancer-related deaths. Vanillylmandelic acid (VMA) and homovanillic acid (HVA) are most commonly analysed in urine of NBL patients. However, their diagnostic sensitivity is suboptimal (82%). Therefore, we performed in-depth analysis of the diagnostic sensitivity of a panel of urinary catecholamine metabolites.

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          Author and article information

          Journal
          Eur. J. Cancer
          European journal of cancer (Oxford, England : 1990)
          Elsevier BV
          1879-0852
          0959-8049
          February 2017
          : 72
          Affiliations
          [1 ] Department of Pediatric Oncology/Hematology, Emma Children's Hospital/Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Laboratory Genetic Metabolic Diseases, Emma Children's Hospital/Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Princess Máxima Center for Pediatric Oncology/Hematology, Lundlaan 6, 3584 EA Utrecht, The Netherlands.
          [2 ] Laboratory Genetic Metabolic Diseases, Emma Children's Hospital/Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
          [3 ] Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Eindhovenweg 20, 2333 ZC Leiden, The Netherlands; Mathematical Institute, Leiden University, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands.
          [4 ] Princess Máxima Center for Pediatric Oncology/Hematology, Lundlaan 6, 3584 EA Utrecht, The Netherlands; University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
          [5 ] Department of Pediatric Oncology/Hematology, Sophia Children's Hospital/Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
          [6 ] Department of Pediatric Oncology/Hematology, VU University Medical Center, De Boelelaan 1118, 1081 HZ Amsterdam, The Netherlands.
          [7 ] Department of Pediatric Oncology/Hematology, Emma Children's Hospital/Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
          [8 ] Department of Pediatric Oncology/Hematology, Emma Children's Hospital/Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Princess Máxima Center for Pediatric Oncology/Hematology, Lundlaan 6, 3584 EA Utrecht, The Netherlands. Electronic address: G.A.M.Tytgat@prinsesmaximacentrum.nl.
          Article
          S0959-8049(16)33069-6
          10.1016/j.ejca.2016.12.002
          28061374
          0545d589-2b1d-442b-b238-b11115220aa9

          Catecholamines,Diagnostic sensitivity,MIBG non-avid tumours,Neuroblastoma,VMA and HVA negative

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