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      Fatty Acid Cytotoxicity to Organ-Cultured Bovine Lenses

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          High sensitivity of cultured bovine and human lens epithelial cells to unsaturated free fatty acids has been reported in previous papers. Here we show that micromolar concentrations of unsaturated free fatty acids also impair lens cells during organ culturing, a system which resembles the in vivo situation much better than cell cultures do. This added weight to the assumption that fatty acid cytotoxicity might be causally related to senile cataract as well as to cataracts associated with systemic diseases.

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          Fatty acid cytotoxicity to human lens epithelial cells

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            Linoleic Acid Cytotoxicity to Bovine Lens Epithelial Cells: Influence of Albumin on Linoleic Acid Uptake and Cytotoxicity

            The high cytotoxicity of linoleic acid (LA) to cultured bovine lens epithelial cells is correlated with high uptake rates for the fatty acid (FA). Both, LA uptake and LA cytotoxicity strongly increase with the increasing LA-to-albumin molar ratio in the culture medium. Cellular uptake and cytotoxicity of LA can be competitively inhibited with the noncytotoxic palmitic acid. The findings may be of interest in view of the low albumin concentration in aqueous humor, resulting in extremely low buffering capacities for free FAs including LA, oleic acid and other cytotoxic cis-unsaturated free FAs, which are strongly raised in pathological situations like diabetes mellitus.
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              Fatty Acid Cytotoxicity to Bovine Lens Epithelial Cells: Investigations on Cell Viability, ecto-ATPase, Na+, K+-ATPase and Intracellular Sodium Concentrations


                Author and article information

                Ophthalmic Res
                Ophthalmic Research
                S. Karger AG
                February 2006
                01 March 2006
                : 38
                : 2
                : 62-65
                Institute of Physiological Chemistry, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle, Germany
                91389 Ophthalmic Res 2006;38:62–65
                © 2006 S. Karger AG, Basel

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                Figures: 3, References: 7, Pages: 4
                Short Communication


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