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Effect of oxygen-glucose deprivation on degranulation and histamine release of mast cells.

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      Abstract

      The purpose of this study was to investigate the effect of oxygen-glucose deprivation (OGD) on degranulation and histamine release of mast cells. Cultured mast cells were exposed to OGD for 1, 2, 4, 8, or 16 h. At 2 h of OGD exposure, the degranulation percentage of mast cells had increased and subsequently showed a progressive further increase, associated with a similar change in lactate dehydrogenase release. Histamine release increased significantly from 1 h of OGD exposure. These results indicate that OGD induces mast cells to degranulate, possibly via a cytotoxic response. This in vitro ischemic model of mast cells might clarify their roles in the pathological processes induced by cerebral ischemia.

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      Affiliations
      [1 ] Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China, 310031.
      Journal
      Cell Tissue Res.
      Cell and tissue research
      Springer Nature
      0302-766X
      0302-766X
      Dec 2005
      : 322
      : 3
      16133147
      10.1007/s00441-005-0041-z

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