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      International society of sports nutrition position stand: caffeine and exercise performance

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          Abstract

          Following critical evaluation of the available literature to date, The International Society of Sports Nutrition (ISSN) position regarding caffeine intake is as follows:

          1. Supplementation with caffeine has been shown to acutely enhance various aspects of exercise performance in many but not all studies. Small to moderate benefits of caffeine use include, but are not limited to: muscular endurance, movement velocity and muscular strength, sprinting, jumping, and throwing performance, as well as a wide range of aerobic and anaerobic sport-specific actions.

          2. Aerobic endurance appears to be the form of exercise with the most consistent moderate-to-large benefits from caffeine use, although the magnitude of its effects differs between individuals.

          3. Caffeine has consistently been shown to improve exercise performance when consumed in doses of 3–6 mg/kg body mass. Minimal effective doses of caffeine currently remain unclear but they may be as low as 2 mg/kg body mass. Very high doses of caffeine (e.g. 9 mg/kg) are associated with a high incidence of side-effects and do not seem to be required to elicit an ergogenic effect.

          4. The most commonly used timing of caffeine supplementation is 60 min pre-exercise. Optimal timing of caffeine ingestion likely depends on the source of caffeine. For example, as compared to caffeine capsules, caffeine chewing gums may require a shorter waiting time from consumption to the start of the exercise session.

          5. Caffeine appears to improve physical performance in both trained and untrained individuals.

          6. Inter-individual differences in sport and exercise performance as well as adverse effects on sleep or feelings of anxiety following caffeine ingestion may be attributed to genetic variation associated with caffeine metabolism, and physical and psychological response. Other factors such as habitual caffeine intake also may play a role in between-individual response variation.

          7. Caffeine has been shown to be ergogenic for cognitive function, including attention and vigilance, in most individuals.

          8. Caffeine may improve cognitive and physical performance in some individuals under conditions of sleep deprivation.

          9. The use of caffeine in conjunction with endurance exercise in the heat and at altitude is well supported when dosages range from 3 to 6 mg/kg and 4–6 mg/kg, respectively.

          10. Alternative sources of caffeine such as caffeinated chewing gum, mouth rinses, energy gels and chews have been shown to improve performance, primarily in aerobic exercise.

          11. Energy drinks and pre-workout supplements containing caffeine have been demonstrated to enhance both anaerobic and aerobic performance.

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          A review of caffeine's effects on cognitive, physical and occupational performance.

          Caffeine is consumed by over 80% of U.S. adults. This review examines the effects caffeine has on cognitive and physical function, since most real-world activities require complex decision making, motor processing and movement. Caffeine exerts its effects by blocking adenosine receptors. Following low (∼40mg or ∼0.5mgkg(-1)) to moderate (∼300mg or 4mgkg(-1)) caffeine doses, alertness, vigilance, attention, reaction time and attention improve, but less consistent effects are observed on memory and higher-order executive function, such as judgment and decision making. Effects on physical performance on a vast array of physical performance metrics such as time-to-exhaustion, time-trial, muscle strength and endurance, and high-intensity sprints typical of team sports are evident following doses that exceed about 200mg (∼3mgkg(-1)). Many occupations, including military, first responders, transport workers and factory shift workers, require optimal physical and cognitive function to ensure success, workplace safety and productivity. In these circumstances, that may include restricted sleep, repeated administration of caffeine is an effective strategy to maintain physical and cognitive capabilities.
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            Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

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              Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption.

              Most individuals adjust their caffeine intake according to the objective and subjective effects induced by the methylxanthine. However, to reach the desired effects, the quantity of caffeine consumed varies largely among individuals. It has been known for decades that the metabolism, clearance, and pharmacokinetics of caffeine is affected by many factors such as age, sex and hormones, liver disease, obesity, smoking, and diet. Caffeine also interacts with many medications. All these factors will be reviewed in the present document and discussed in light of the most recent data concerning the genetic variability affecting caffeine levels and effects at the pharmacokinetic and pharmacodynamic levels that both critically drive the level of caffeine consumption. The pharmacokinetics of caffeine are highly variable among individuals due to a polymorphism at the level of the CYP1A2 isoform of cytochrome P450, which metabolizes 95% of the caffeine ingested. Moreover there is a polymorphism at the level of another critical enzyme, N-acetyltransferase 2. At the pharmacodynamic level, there are several polymorphisms at the main brain target of caffeine, the adenosine A2A receptor or ADORA2. Genetic studies, including genome-wide association studies, identified several loci critically involved in caffeine consumption and its consequences on sleep, anxiety, and potentially in neurodegenerative and psychiatric diseases. We start reaching a better picture on how a multiplicity of biologic mechanisms seems to drive the levels of caffeine consumption, although much more knowledge is still required to understand caffeine consumption and effects on body functions.
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                Author and article information

                Contributors
                nanci.guest@mail.utoronto.ca
                Journal
                J Int Soc Sports Nutr
                J Int Soc Sports Nutr
                Journal of the International Society of Sports Nutrition
                BioMed Central (London )
                1550-2783
                2 January 2021
                2 January 2021
                2021
                : 18
                : 1
                Affiliations
                [1 ]GRID grid.17063.33, ISNI 0000 0001 2157 2938, Department of Nutritional Sciences, Faculty of Medicine, , University of Toronto, ; 1 King’s College Circle, Room 5326A, Toronto, ON M5S 1A8 Canada
                [2 ]GRID grid.258509.3, ISNI 0000 0000 9620 8332, Department of Exercise Science and Sport Management, , Kennesaw State University, ; Kennesaw, GA 30144 USA
                [3 ]GRID grid.476939.6, ISNI 0000 0004 4914 737X, Carrick Institute, ; Cape Canaveral, FL 32920 USA
                [4 ]GRID grid.1019.9, ISNI 0000 0001 0396 9544, Institute for Health and Sport (IHES), , Victoria University, ; Melbourne, Australia
                [5 ]GRID grid.259030.d, ISNI 0000 0001 2238 1260, Department of Health Sciences, , CUNY Lehman College, ; Bronx, NY 10468 USA
                [6 ]GRID grid.214572.7, ISNI 0000 0004 1936 8294, Department of Health and Human Physiology, , University of Iowa, ; Iowa City, IA 52240 USA
                [7 ]GRID grid.254567.7, ISNI 0000 0000 9075 106X, Department of Exercise Science, Arnold School of Public Health, , University of South Carolina, ; Colombia, SC 29208 USA
                [8 ]GRID grid.417900.b, School of Social and Health Sciences, , Leeds Trinity University, ; Leeds, UK
                [9 ]GRID grid.261241.2, ISNI 0000 0001 2168 8324, Exercise and Sport Science, , Nova Southeastern University, ; Davie, FL 33314 USA
                [10 ]GRID grid.170430.1, ISNI 0000 0001 2159 2859, Institue of Exercise Physiology and Rehabilitation Science, , University of Central Florida, ; Orlando, FL 32816 USA
                [11 ]Stronger by Science LLC, Raleigh, NC USA
                [12 ]GRID grid.410711.2, ISNI 0000 0001 1034 1720, Department of Exercise and Sport Science, Applied Physiology Laboratory, , University of North Carolina, ; Chapel Hill, NC 27599 USA
                [13 ]GRID grid.261241.2, ISNI 0000 0001 2168 8324, Nutrion Department, College of Osteopathic Medicine, , Nova Southeastern University, ; Fort Lauderdale, FL 33314 USA
                [14 ]Scientific Affairs. Nutrasource, Guelph, ON Canada
                [15 ]GRID grid.170693.a, ISNI 0000 0001 2353 285X, Performance & Physique Enhancement Laboratory, , University of South Florida, ; Tampa, FL 33612 USA
                Author information
                http://orcid.org/0000-0002-1745-862X
                Article
                383
                10.1186/s12970-020-00383-4
                7777221
                33388079
                06049b04-4c2f-4c5c-84e6-2d3a0a4189b8
                © The Author(s) 2021

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 23 October 2020
                : 31 October 2020
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                © The Author(s) 2021

                Sports medicine
                Sports medicine

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