For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
1
views
37
references
 Top references
cited by
1
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      77
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Antisynthetase Syndrome Post Shingrix and Pneumovax Vaccinations, Possible Correlation

      case-report
      Author(s): 1 , 1 , 1 , , 2
      Editor(s): ,
      Publication date (Electronic, pub):
      Publication date (Electronic, collection):
      Journal: Cureus
      Publisher: Cureus
      Keywords: interstitial lung disease (ild), anti-jo-1 antibody, autoimmune disease, vaccination, antisynthetase syndrome (ass)

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          This is a case report of a patient who developed acute progressive shortness of breath that started two days following the administration of Shingrix and Pneumovax vaccinations. Eight days after the onset of his symptoms he was diagnosed with acute interstitial pneumonitis based on CT scan of the chest which later appeared to be consistent with the diagnosis of antisynthetase syndrome in light of findings consistent with mechanic's hands on examination, elevated Anti-Jo-1 antibody titers and aldolase on laboratory studies.

          Related collections

          Most cited references37

          • Record: found
          • Abstract: found
          • Article: not found

          Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years?

          Lisa Christopher-Stine, Helen R Connors, Chester V Oddis … (2010)
          Interstitial lung disease is commonly associated with the autoimmune inflammatory myopathies dermatomyositis and polymyositis and accounts for significant morbidity and mortality in these conditions. In the 35 years since the association between inflammatory myopathy and interstitial lung disease was initially described, there has been progress in diagnosing and treating this dis-order. Nevertheless, there remains much about pathogenesis and therapeutics to be learned. This review examines the changes in the understanding of this complex condition, highlighting recent advances and areas deserving of further study.
          Article 0 comments Cited 93 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Consequence or coincidence? The occurrence, pathogenesis and significance of autoimmune manifestations after viral vaccines.

            Ami Schattner (2005)
            Viruses and virus-induced lymphokines may have an important role in the pathogenesis of autoimmunity (Schattner A. Clin Immunol Immunopathol; 1994). The occurrence and significance of autoimmune manifestations after the administration of viral vaccines remain controversial. Medline search of all relevant publications from 1966 through June 2004 with special emphasis on search of each individual autoimmune manifestation and vaccination, as well as specifically searching each viral vaccine for all potential autoimmune syndromes reported. All relevant publications were retrieved and critically analyzed. The most frequently reported autoimmune manifestations for the various vaccinations, were: hepatitis A virus (HAV)--none; hepatitis B virus (HBV)--rheumatoid arthritis, reactive arthritis, vasculitis, encephalitis, neuropathy, thrombocytopenia; measles, mumps and rubella vaccine (MMR)--acute arthritis or arthralgia, chronic arthritis, thrombocytopenia; influenza--Guillain-Barre syndrome (GBS), vasculitis; polio--GBS; varicella--mainly neurological syndromes. Even these 'frequent' associations relate to a relatively small number of patients. Whenever controlled studies of autoimmunity following viral vaccines were undertaken, no evidence of an association was found. Very few patients may develop some autoimmune diseases following viral vaccination (in particular - arthropathy, vasculitis, neurological dysfunction and thrombocytopenia). For the overwhelming majority of people, vaccines are safe and no evidence linking viral vaccines with type 1 diabetes, multiple sclerosis (MS) or inflammatory bowel disease can be found.
            Article 0 comments Cited 61 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Myositis-related interstitial lung disease and antisynthetase syndrome.

              Joshua Solomon, Jeffrey Swigris, Kevin K Brown (2024)
              In patients with myositis, the lung is commonly involved, and the presence of anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies marks the presence or predicts the development of interstitial lung disease (ILD). A distinct clinical entity-antisynthetase syndrome-is characterized by the presence of anti-ARS antibodies, myositis, ILD, fever, arthritis, Raynaud's phenomenon, and mechanic's hands. The most common anti-ARS antibody is anti-Jo-1. More recently described anti-ARS antibodies might confer a phenotype that is distinct from that of anti-Jo-1-positive patients and is characterized by a lower incidence of myositis and a higher incidence of ILD. Among patients with antisynthetase syndrome-related ILD, the response to immunosuppressive medications is generally, but not universally, favorable.
              Article 0 comments Cited 61 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Cureus
                Journal ID (iso-abbrev): Cureus
                Journal ID (issn): 2168-8184
                Title: Cureus
                Publisher: Cureus (Palo Alto (CA) )
                ISSN (Electronic): 2168-8184
                Publication date (Electronic, pub): 17 May 2022
                Publication date (Electronic, collection): May 2022
                Volume: 14
                Issue: 5
                Electronic Location Identifier: e25085
                Affiliations
                [1 ] Internal Medicine, AdventHealth Orlando, Orlando, USA
                [2 ] Rheumatology, AdventHealth Orlando, Orlando, USA
                Author notes
                Article
                DOI: 10.7759/cureus.25085
                PMC ID: 9203250
                PubMed ID: 35719791
                SO-VID: 061d1a7f-b3e2-453f-bbf0-adadadea54c3
                Copyright © Copyright © 2022, Osman et al.
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                Date accepted : 16 May 2022
                Categories
                Subject: Internal Medicine
                Subject: Allergy/Immunology
                Subject: Rheumatology

                Keywords: interstitial lung disease (ild),anti-jo-1 antibody,autoimmune disease,vaccination,antisynthetase syndrome (ass)
                Data availability:
                Keywords: interstitial lung disease (ild), anti-jo-1 antibody, autoimmune disease, vaccination, antisynthetase syndrome (ass)

                Comments

                Comment on this article

                scite_

                Similar content77

                See all similar

                Cited by1

                See all cited by

                Most referenced authors313

                See all reference authors