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      • Record: found
      • Abstract: found
      • Article: found

      Susceptibility of +/+, +/nu and nu/nu BALB/c Mice to Ocular Herpes simplex Virus Infection

      research-article
      Author(s):
      Publication date (Electronic):
      Journal: Ophthalmic Research
      Publisher: S. Karger AG
      Keywords: Herpes simplexvirus, Ocular infections, Nude mouse, Herpetiform spread

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          Abstract

          Athymic (nude) mice have played an important role in defining the function of the immune system and its role in infectious diseases. In the majority of these studies, heterozygous +/nu mice have been used as normal controls for the nu/nu mice, and it has been assumed that +/nu mice have essentially normal immune systems. We have compared the response of +/+, +/nu and nu/nu BALB/c mice following ocular infection with HSV-1 and have found that +/nu mice develop significantly more severe blepharitis, vascularization of the cornea, stromal keratitis and extraocular disease (herpetiform spread) than +/+ BALB/c mice. The extraocular disease was particularly severe in the +/nu mice, suggesting that factors regulating herpetiform spread of the virus are deficient in these mice. Susceptibility to lethal encephalitis did not differ between +/+ and +/nu mice. These results suggest that significant differences exist in the response to ocular HSV infection between +/+ and +/nu mice.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1992
          Publication date (Print): 1992
          Publication date (Electronic): 10 December 2009
          Volume: 24
          Issue: 6
          Pages: 332-337
          Affiliations
          Departments of Ophthalmology and Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisc., USA
          Article
          Publisher ID: 267189 Other ID: Ophthalmic Res 1992;24:332–337
          DOI: 10.1159/000267189
          PubMed ID: 1287512
          SO-VID: 06f24e08-823d-49a4-a1ab-3006cada1356
          Copyright © © 1992 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 20 February 1992
          Date accepted : 09 June 1992
          Page count
          Pages: 6
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Herpes simplexvirus,Nude mouse,Herpetiform spread,Ocular infections
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Herpes simplexvirus, Nude mouse, Herpetiform spread, Ocular infections

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