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      Fluorescent and photoacoustic bifunctional probe for the detection of ascorbic acid in biological fluids, living cells and in vivo.

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          Abstract

          Photoacoustic imaging (PAI) has emerged as a promising clinical technology, thanks to its high-resolution in deep tissues. However, the lack of specificity towards analytes limits further application of the PA probe in molecular imaging. To this end, we herein report a PA and fluorescence (FL) dual-modal probe for the selective detection of ascorbic acid (AA). To realize this design, cobalt oxyhydroxide (CoOOH) was adopted as a multifunctional platform (PA contrast agent, FL quencher and specific oxidant to AA) and hybridized with red-emissive carbon dots (RCDs). In the presence of AA, CoOOH is reduced to Co2+ and meanwhile releases RCDs, resulting in the decrease of PA and recovery of FL signals. We demonstrated the AA detection capabilities of the probe in complicated biological fluids (human serum and urine), living cells, and dual-modal FL/PA imaging in vivo. This work revealed the PAI capacity of CoOOH for the first time, which may inspire researchers to design other CoOOH-based PA probes and further employ RCDs in biology and the clinic.

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          Author and article information

          Journal
          Nanoscale
          Nanoscale
          Royal Society of Chemistry (RSC)
          2040-3372
          2040-3364
          Sep 27 2018
          : 10
          : 37
          Affiliations
          [1 ] Key Laboratory of Graphene Technologies and Applications of Zhejiang Province, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, Ningbo 315201, P. R. China. wangyuhui@nimte.ac.cn linhengwei@nimte.ac.cn.
          Article
          10.1039/c8nr03435d
          30221263
          071c33b1-d65d-4d38-8934-760179b61200
          History

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