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      LncRNA TMPO‐AS1 serves as a ceRNA to promote osteosarcoma tumorigenesis by regulating miR‐199a‐5p/WNT7B axis

      1 , 2

      Journal of Cellular Biochemistry

      Wiley

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          Most cited references 36

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          Long Noncoding RNAs in Cancer Pathways.

          Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer-associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer.
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            MicroRNAs

             David Bartel (2004)
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              Future directions in the treatment of osteosarcoma.

              Overall survival rates for osteosarcoma have remained essentially unchanged over the past 3 decades despite attempts to improve outcome via dose intensification and modification based on response. This review describes recent findings from contemporary clinical trials, advances in the comprehension of osteosarcoma biology and genomic complexity, and potential opportunities using targeted and immune-mediated therapies.
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                Author and article information

                Contributors
                Journal
                Journal of Cellular Biochemistry
                J Cell Biochem
                Wiley
                0730-2312
                1097-4644
                November 06 2019
                March 2020
                November 03 2019
                March 2020
                : 121
                : 3
                : 2284-2293
                Affiliations
                [1 ]Department of OrthopedicsShengli Oil field Central Hospital Dongying City Shandong Province China
                [2 ]Department of OrthopedicsNinth Hospital of Xi'an Xi'an City Shaanxi Province China
                Article
                10.1002/jcb.29451
                © 2020

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