Projected Cancer Incidence Rates and Burden of Incident Cancer Cases in HIV-Infected Adults in the United States Through 2030

Abstract

<div class="section"> <a class="named-anchor" id="S1"> <!-- named anchor --> </a> <h5 class="section-title" id="d2632459e188">Background:</h5> <p id="P15">Persons living with HIV (PLWH) have an elevated risk for certain types of cancer. With modern antiretroviral therapy, PLWH are aging and cancer rates are changing. </p> </div><div class="section"> <a class="named-anchor" id="S2"> <!-- named anchor --> </a> <h5 class="section-title" id="d2632459e193">Objective:</h5> <p id="P16">To project cancer incidence rates and burden (number of new cancer diagnoses) among adult PLWH in the United States through 2030. </p> </div><div class="section"> <a class="named-anchor" id="S3"> <!-- named anchor --> </a> <h5 class="section-title" id="d2632459e198">Design:</h5> <p id="P17">Descriptive.</p> </div><div class="section"> <a class="named-anchor" id="S4"> <!-- named anchor --> </a> <h5 class="section-title" id="d2632459e203">Setting:</h5> <p id="P18">HIV/AIDS Cancer Match Study to project cancer rates and HIV Optimization and Prevention Economics model to project HIV prevalence. </p> </div><div class="section"> <a class="named-anchor" id="S5"> <!-- named anchor --> </a> <h5 class="section-title" id="d2632459e208">Participants:</h5> <p id="P19">HIV-infected adults.</p> </div><div class="section"> <a class="named-anchor" id="S6"> <!-- named anchor --> </a> <h5 class="section-title" id="d2632459e213">Measurements:</h5> <p id="P20">Projected cancer rates and burden among HIV-infected adults in the United States by age during 2006 to 2030 for AIDS-defining cancer (ADC; that is, Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer) and certain types of non–AIDS-defining cancer (NADC). All other cancer types were combined. </p> </div><div class="section"> <a class="named-anchor" id="S7"> <!-- named anchor --> </a> <h5 class="section-title" id="d2632459e218">Results:</h5> <p id="P21">The proportion of adult PLWH in the United States who are aged 65 years or older is projected to increase from 8.5% in 2010 to 21.4% in 2030. Age-specific rates are projected to decrease through 2030 across age groups for Kaposi sarcoma, non-Hodgkin lymphoma, cervical cancer, lung cancer, Hodgkin lymphoma and other cancer types combined, and among those aged 65 years or older for colon cancer. Prostate cancer rates are projected to increase. The estimated total cancer burden in PLWH will decrease from 8150 cases in 2010 (2730 of ADC and 5420 of NADC) to 6690 cases in 2030 (720 of ADC and 5980 of NADC). In 2030, prostate cancer ( <i>n</i> = 1590) and lung cancer ( <i>n</i> = 1030) are projected to be the most common cancer types. </p> </div><div class="section"> <a class="named-anchor" id="S8"> <!-- named anchor --> </a> <h5 class="section-title" id="d2632459e229">Limitation:</h5> <p id="P22">Projections assume that trends in current cancer incidence rates, HIV transmission, and survival will continue. </p> </div><div class="section"> <a class="named-anchor" id="S9"> <!-- named anchor --> </a> <h5 class="section-title" id="d2632459e234">Conclusion:</h5> <p id="P23">The cancer burden among PLWH is projected to shift, with prostate and lung cancer expected to emerge as the most common types by 2030. Cancer will remain an important comorbid condition, and expanded access to HIV therapies and cancer prevention, screening, and treatment is needed. </p> </div><p id="P24">Persons living with HIV (PLWH) have a greatly improved life expectancy due to the introduction of potent antiretroviral drug therapies. Projecting future rates and number of incident diagnoses of both AIDS-defining and non–AIDS defining cancer in PLWH is important in order to inform the design of programs for prevention, screening, and treatment. </p>